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M2 Endo Pharm > Womens Health > Flashcards

Flashcards in Womens Health Deck (18)
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1
Q

OC

  • whats inside
  • adverse effects (5)
  • –moderate ones (3)
  • ——serious (5)
  • contraindications (7)
  • metabolism
A

Ethynyl E2 and possibly some P4 variant\

HA, N, mastalgia, edema
-breakthrough bleeding, withdrawl bleeding failing to

weight gain+acne+hirustisim (P4 like prgestins), urethral dilations->bacteruria, ammonoreha for several months after stopping

low incidence-Venous thrombomolic disease, MI, Cerebrovascular disease, Gi d/o, depression

CV, Cerebrovascular, thromboembolic hx
Migrane with aura, liver/gallbaldder disease, htn

cyp3a4

2
Q

OC benefits unrealted to contraception (3 main) and 4ish others

A

reduce risk of-ovarian cysts, endometrial and breast cancer

lower incidence of ectopic preg

prementstual sdx, dysmenorrhea, and endometriosis may be ameliorated

acne and hirsutism may be ameliorated

3
Q

Ortho Evra

  • what is it
  • mech
  • usage
A

Transdermal patch

Synthetic ethynyl estradio l adn P4 at high leve (but goes through slowly)

3 wks with pathc, 1 week off

4
Q

Nuvaring

  • what is it
  • usage
A

Flexible ring with ehtinyl E2 and P4

insert ring for 3 weeks and 4th week is ring free

5
Q

Implanon

  • aka
  • what is it
  • usage
A

Nexplanon-subdermal implant

contains ONLY progestin

peka serum concetration in first few weeks-3 year ovulation supression

6
Q

Depo Provera

  • what is it (and what in it)
  • usage
  • adv
  • disadv
A

Injectable

progestin only

Im admin 1x/3mo

long duratio nof action and decreased menses

decreased bone density, weight gain, menstural irreg, depression, doctor admin

7
Q

Levonorgestrel

A

Morning after pill (can be e2, p4, or both)

LEvo is just P4

99% effective

8
Q

Mifepristone

A

P4 receptor antagonist=luteolytic effect->effective postcoital contraceptive

9
Q

Clomiphene

  • what is it
  • mech
  • uses
  • dose
  • side fx
A

SERM-selective E2 receptor modulator

increase in secretion of gonadotropins and E2 by inhibiting E2 negative feedback effect

stim ovulation in oligomenorhrhea/amenorrhea and ovulatory dysfxn

-single course=somnge ovulation-do repeatedly until preg

hotflashes, NV, dperession, heavy meses, weight gainm multiple preg

10
Q

Leuprolide

  • what is it
  • use
A

GnRH agaonist

for anovulatory women who fail to respond to other less complicated forms of trx
- MC use is controled ovarian hyperstim for IVF

11
Q

Ceftrixaone

A

3rd gen cephalosprin
-inhibit biosyn of bacerial cell wall (cidal)

PID-gonorrhea

12
Q

Azyhthomycin and Doxy

  • use
  • mech
  • metabolism
  • cidal vs static
A

PID-CLAP

Azithromycin-macrolide-protein synthesis inhibitor 50s ribosomal subinit

Doxycycline-target 30S ribosomal subunit

both are long acting and orally bioavilie

bacteriostatic

13
Q

STDs that cause vaginal discharge and trx

A

CLAP and gonorrhea

Trichomonas vaginitis

  • flagellated protozoan
  • malodorous discharge
  • metronidazone

Herpes vaginitis-acyclovir, valacyclovir, famiciclovir

14
Q

Metronidazole

  • mech
  • useage
  • dosage
  • side fx
  • rare side fx
  • contradincation
A
  • pyruvate ferredoxin oxidorreductase (PFOR) is required-found isn susceptible microbes
  • activation using ferredoxin as electron donor results in toxic radical
  • chews up DNA

trx Trich

single dose

GI irritation (kills enteric microflora)-lessened with food, HA

neutropenia, pancreatitis, CNS tox

(12 hour window)Nursing, Preg, CNS disease

15
Q

herpes Vaginitis trx

  • microbe
  • mech
  • difference between 3 types
  • doses
  • 3 effects
  • side fx
  • special side fx
A

get it from HSV2

acyclovir, valacyclovir, famcicvlor

  • competitiive inhibition of DNA polyermase of virus
  • needs viral kinase to work
  • chain termination after incorporation

Van and fam-are prodrugs of acyclovir

acyclovir 3x daily, fam 3x, vala 1x daily (best)

shorter duration, reduced ulcer heal time, decrease transmission

N, V, D, HA (eat before)

high dose valacyclovir-confusion ,hallucinations, seizures

16
Q

tamoxifen use

A

E2 + breast cancer

but agonist in endometrium

17
Q

Fenesteride mech and use

A

5alpha reductase inhibitor
- no DHT production

trx BPH

takes months to work

18
Q

anastrazole

A

CYP19 inhibitor