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Flashcards in Vulnerable plaque article Deck (6)
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1

The loss of the protective endothelial covering allows blood to come in contact with the highly thrombogenic contents of collagen and/or necrotic core of the plaque and luminal thrombosis to occur. This occurs with either plaque rupture or plaque erosion, both of which are considered __________ __________.

vulnerable plaques

2

Other mechanisms of ACS, such as a ______-______ ________, may be causative.

supply-demand mismatch

3

______ ______ is the major cause of acute coronary thrombi (70%).

plaque rupture

It is characterized by lesions that exhibit relatively large necrotic cores with a thin disrupted fibrous cap. Luminal blood comes in direct communication with the necrotic core and thrombosis may result.

4

The precise pathogenetic mechanism of plaque rupture is ______.

Unclear

Factors such as the destruction of extracellular matrix within the fibrous cap by metalloproteinases as well as macrophage apoptosis and the influence of local rheological forces are likely involved.

5

Ruptured plaques are associated with positive remodeling. Thus a high percentage of acute coronary syndromes are seen attributed to plaque rupture occur in lesions with ___% percent diameter stenosis. 

50%

Repeat ruptures, which may or may not be silent, are likely responsible for plaque progression and the formation of obstructive lesions.

6

Pathogenetic mechanisms of plaque erosion are ______ __________.

poorly understood

The presence of hyaluronan in the superficial layers close to the thrombus suggests their role in deendothelialization and platelet adherence.