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Flashcards in viral URT infections Deck (45)
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1

treat adenovirus

symptomatic

2

rhinovirus structure

nonenveloped, icosahedral capsule +ssRNA genome small size temperature sensitive

3

treatment for rhinovirus

symptomatic sanitation helps prevent spread

3

respiratory syncytial virus (RSV)

paramyovirus family

3

summary = rhinovirus, RSV, adenovirus, EBV site of replication for each

cyto - rhino, rsv nucleus - adeno, ebv

4

respigam vs palivizumab (synagis)

prevents RSV Synagis>x100>> respigam s- monoclonal ab (anti F reactive ab) r- polyclonal ab

4

adenovirus structure

ds linear DNA genome icosahedral capsid, largest nonenveloped virus replicates in nucleus

4

diagnosis for rhinovirus, rsv, adenovirus, ebv

rhino - symptoms rsv - antigen detection by ELISA/IFA, viral culture, PCR adeno - antigen detection by ELISA/IFA, viral culture, PCR ebv - heterophile Ab, atypical lymphocytes, Ab viz ELISA, PCR

5

what causes 1/3 of all adult common colds?

rhinovirus

5

what encodes its own dna dependent dna polymerase?`

ebv

6

what causes infectious mononucleosis

ebv

7

pathogenesis of RSV

entry as aerosol/fomite via nose/eye epithelia self limiting infection, 7-10 days causes runny nose, fever, rapid breathing, wheezing, coughing, lips turn blue

8

primary receptor for ebv infection

CD21 (CR2)

10

how is rhinovirus transmitted?

aerosol droplets and direct contact many cases coincide with sept to april school year

11

rhinovorus causes these inflammatory responses:

nasal discharge and congestion sneezing, sore throat edema, erythema aches, fatigue, loss of appetite

12

diagnose RSV

anitgens in nasal swab or aspirate use DFA or ELISA viral culture PCR

12

immunity for adenovirus

by 10, most have antibodies against common serotypes cell mediated CD8 CTL response controls infections

13

diagnosis adenovirus

antigen detected in aspirate/throat swab virus isolation serology - complement fixation test pcr

13

EBV structure

enveloped large genome linear dsDNA icosahedral capsid encodes its own dna dependent dna polymerase replicates inside nucleus?

14

genes expressed in EBV latency

EBERs or EBNA1(type 1 burkitt lymphoma)

16

what location does rhinovirus prefer and why?

grows and replicates better in NOSE at 88-90 degrees than at 98 in the lungs temperature sensitive

17

adolesent infection leading to infectious mononucleosis that causes EBV

kissing disease

18

rhinovirus encodes its own_______?

rna polymerase

20

why do rsv infections repeat alot?

protective immunity is shortlived

20

epstein barr virus (ebv)

a herpes virus infects epithelial cells and lymphocytes lays latent

22

primary site for RSV replication?

nasopharyngeal epithelium

23

diagnosis for infectious mononucleosis

1) atypical lymphocytes (downey cells = cd8 ctl) 2) agglutination test for heterophile Ab 3) EBV antibody ELISA 4) PCR

24

clinical presentation for each: rhinovirus, rsv, adenovirus, ebv

rhino - cold like rsv - URT, croup, bronchiolitis adeno - pharyngitis, conjunctavitis, ARD, pneumonia ebv - infectious mono, exudative pharyngitis, cervial, lymphadenopathy

26

respiratory syncytial virus structure

enveloped, helical capsule -ssRNA genome two envelope proteins = F (fusion) and G(attachment) forms syncytium

27

transmission of adenovirus?

direct contact - fecal-oral, contaminated water, aerosol droplets epidemic in military facilites