nonenveloped, icosahedral capsule +ssRNA genome small size temperature sensitive
treatment for rhinovirus
symptomatic sanitation helps prevent spread
respiratory syncytial virus (RSV)
summary = rhinovirus, RSV, adenovirus, EBV site of replication for each
cyto - rhino, rsv nucleus - adeno, ebv
respigam vs palivizumab (synagis)
prevents RSV Synagis>x100>> respigam s- monoclonal ab (anti F reactive ab) r- polyclonal ab
ds linear DNA genome icosahedral capsid, largest nonenveloped virus replicates in nucleus
diagnosis for rhinovirus, rsv, adenovirus, ebv
rhino - symptoms rsv - antigen detection by ELISA/IFA, viral culture, PCR adeno - antigen detection by ELISA/IFA, viral culture, PCR ebv - heterophile Ab, atypical lymphocytes, Ab viz ELISA, PCR
what causes 1/3 of all adult common colds?
what encodes its own dna dependent dna polymerase?`
what causes infectious mononucleosis
pathogenesis of RSV
entry as aerosol/fomite via nose/eye epithelia self limiting infection, 7-10 days causes runny nose, fever, rapid breathing, wheezing, coughing, lips turn blue
primary receptor for ebv infection
how is rhinovirus transmitted?
aerosol droplets and direct contact many cases coincide with sept to april school year
rhinovorus causes these inflammatory responses:
nasal discharge and congestion sneezing, sore throat edema, erythema aches, fatigue, loss of appetite
anitgens in nasal swab or aspirate use DFA or ELISA viral culture PCR
immunity for adenovirus
by 10, most have antibodies against common serotypes cell mediated CD8 CTL response controls infections
antigen detected in aspirate/throat swab virus isolation serology - complement fixation test pcr
enveloped large genome linear dsDNA icosahedral capsid encodes its own dna dependent dna polymerase replicates inside nucleus?
genes expressed in EBV latency
EBERs or EBNA1(type 1 burkitt lymphoma)
what location does rhinovirus prefer and why?
grows and replicates better in NOSE at 88-90 degrees than at 98 in the lungs temperature sensitive
adolesent infection leading to infectious mononucleosis that causes EBV
rhinovirus encodes its own_______?
why do rsv infections repeat alot?
protective immunity is shortlived
epstein barr virus (ebv)
a herpes virus infects epithelial cells and lymphocytes lays latent
primary site for RSV replication?
diagnosis for infectious mononucleosis
1) atypical lymphocytes (downey cells = cd8 ctl) 2) agglutination test for heterophile Ab 3) EBV antibody ELISA 4) PCR
clinical presentation for each: rhinovirus, rsv, adenovirus, ebv
rhino - cold like rsv - URT, croup, bronchiolitis adeno - pharyngitis, conjunctavitis, ARD, pneumonia ebv - infectious mono, exudative pharyngitis, cervial, lymphadenopathy
respiratory syncytial virus structure
enveloped, helical capsule -ssRNA genome two envelope proteins = F (fusion) and G(attachment) forms syncytium
transmission of adenovirus?
direct contact - fecal-oral, contaminated water, aerosol droplets epidemic in military facilites