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Flashcards in Viral Diseases Deck (12)
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1

three types of viral diseases

pneumotropic
dermatropic
viscerotropic

2

Influenza

acute, contagious disease of URT
transmitted by resp. droplets
enveloped ssRNA
not a reterovirus

3

types of influenza

Type A - infects birds, humans and pigs
Type B - no subtypes, infects humans
Type C - rare, mild disease in humans

4

types of proteins associated with influenza

Hemaglutnin - clumps RBC, attachment to host cell
Neuraminidase - entry and exit of virions in/out of host cell

both are antigenic

5

what is antigenic drift

minor mutations
year to year variations

6

antigenic shift

major mutations, reassortment
pandemic possibility

7

manifestations for influenza

abrupt onset
chills, fatigue, headache, pain in chest, severe hacking cough, increase in body temp (40 degrees)
1-2 weeks
risk of secondary inf. in young and old

8

Serious complications of Influenza
Guillian-Barr Syndrome

GBS
-neurological symptoms, polio-like paralysis
-usually reversible

9

Reys syndrome

-also neuro
-in children following flu or chicken pox
-child experiences repeated vomitting,lethargy,disoriented, combativeness
-associated with ASA

10

deaths due to influenza

40,000/yr in NA
90% are 65 yrs or older

11

Rhinoviruses

30% of total common colds
-nonenveloped ssRNA
similar to flu virus

12

Adenoviruses

-nonenveloped dsDNA
-common cold
-spread by resp. or ocular secretions(can cause conjunctivitis)
-cause of viral meningitis
-good candidate for 'gene therapy'
-attenuated virus is infectious but not contagious
-dsDNA for gene insertion/read for protein production
-candidates for gene therapy = single gene disease such as:Hemophilia, cystic fibrosis, muscular dystrophy