Uses of Protein Structure Flashcards Preview

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Flashcards in Uses of Protein Structure Deck (9)
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1
Q

NMR/X ray crystallography

A

Structure of protein/binding interactions

AND surface not used for binding

Can modify these

2
Q

Structure is important becuase

A

Used when you have lead compound

Can design structure from random protein-no lock and key

3
Q

Potential drug steps

A
screen vs target protein
lead compound
find strcuture
redisgn
synthesis
test
prelinical
clincal
drug
4
Q

surfaces not used for binding function in designing drugs

A

change solubility and other nonbonding things

5
Q

diabetes

A

muscles decrease glucose uptake

pacnrease stops making functional insulin

liver increases glucose production

MI, stroke, vision loss, etc

6
Q

GLP1/GIP

A

Produced in stomach

Regulate glucose and apetite

Degraded by DPP4 quickly

7
Q

DPP4 in mouse trials

A

great-left GLP/GIP in system to good benefits

toxic to higher order species

8
Q

Ideal drug characteristics (really 3)

A

improve binding

good pharmokinetc props (solubility/permeability)

specificity up

combat drug resistance

stabiltze vaccine

9
Q

DPP4 story

A

got 2 lead components

crsyallize binding of DPP4 with target proteins

took parts from 2 lead components that were the binding regions

final product way different but had some key structures that were initial two lead components