Tumors of Odontogenic Epithelium Flashcards Preview

AU 16- Oral Path MT 3 > Tumors of Odontogenic Epithelium > Flashcards

Flashcards in Tumors of Odontogenic Epithelium Deck (38)
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1
Q

Name three tumors of Odontogenic Epithelium.

A

Ameloblastoma
Adenomatoid Odontogenic Tumor (AOT)
Calcifying Epithelial Odontogenic Tumor (CEOT)

2
Q

What is an ameloblastoma?

A

benign but locally aggressive neoplasm of odontogenic epithelial origin that histologically resembles the ameloblasts of the enamel organ

3
Q

True or False: Enamel is produced by the lesional cells of an ameloblastoma.

A

False!

4
Q

True or False: The frequency of ameloblastoma equals the combined frequency of all other odontogenic tumors.

A

True

common of odontogenic tumors, yet still only 0.2% of oral pathology

5
Q

What is the average age at time of diagnosis for ameloblastoma?

A

33 years old

6
Q

Where do most ameloblastomas occur?

A
  • in the mandible (molar-ramus region)

- some (20%) occur in association with an impacted tooth

7
Q

Ameloblastoma grows _____ with _____.

A

slowly
expansion/swelling

(posterior mandible:
no expansion = OKC, expansion = ameloblastoma)

8
Q

Ameloblastomas appear as a small radiolucency with well-defined borders, then become expansile and develop the ______ or _____ (multilocular) appearance.

A

soap bubble

honeycomb

9
Q

Several microscopic patterns have been seen with ameloblastoma but ______ or ______ are seen most often.

A

plexiform

follicular

10
Q

What is special about the nuclei in ameloblastomas?

A

nuclei are polarized AWAY from the basement membrane

11
Q

Loosely arranged polyhedral epithelial cells of ameloblastomas resemble _____ ______.

A

stellate reticulum

12
Q

What is the recommended treatment for ameloblastoma?

A

depends on the size and location
small = aggressive curettage or small en bloc resection
large = large en bloc or segmental resection with reconstruction

13
Q

True or False: Mandibular ameloblastomas should be treated more aggressively.

A

False: maxillary should be treated more aggressively due to their anatomic location

14
Q

With simple curettage, the recurrence rate of small ameloblastoma is ______%.

A

55-90%

15
Q

With marginal resection, recurrence rates are up to ____%.

A

15

16
Q

True or False: Ameloblastoma can be fatal.

A

True, maxillary lesions are more of a concern

17
Q

Yearly follow-up for ameloblastoma is should last ______ years; there is rare malignant transformation.

A

8 to 10 years

18
Q

A _______ ameloblastoma can look like many other gingival bumps.

A

peripheral

19
Q

Peripheral ameloblastoma is an aysmptomatic gingival mass in a _______-aged adult that includes _____tissues with little to no _____ involvement.

A

middle-aged
soft tissues
no bone

20
Q

What is the typical size for ameloblastoma?

A

less than 2 cm in diameter

21
Q

True or False: Peripheral ameloblastoma is an innocuous lesion that can easily be cured by local excision.

A

True

22
Q

What does AOT stand for?

A

Adenomatoid Odontogenic Tumor

23
Q

Adenomatoid Odontogenic Tumors arise from ______ or ______.

A

enamel organ

dental lamina rests

24
Q

True or False: AOT is more common in young patients under the age of 20 years.

A

True

25
Q

Does AOT have a sex predilection?

A

yes, more likely in females (2:1)

26
Q

The _____ maxilla is the most common location for AOT.

A

anterior

27
Q

____% of AOT are associated with anterior jaws, ____% are associated with an impacted tooth.

A

75%
75%
AOT FAM = female, anterior, maxilla

28
Q

How can an AOT be differentiated from a dentigerous cyst?

A

Radiograph:
AOT extends apically beyond the CEJ,
dentigerous stops at the CEJ

29
Q

AOT tumor cells form swirling spindle-cell nests that contain ________ structures of varying sizes.

A

duct-like

and sometimes foci of basophilic calcified material is also seen

30
Q

True or False: AOT is treated by enucleation with rare recurrence.

A

True

31
Q

True or False: The Pindborg Tumor is a rare odontogenic epithelial neoplasm.

A

True

32
Q

The histogenesis of a Pindborg Tumor (CEOT) is thought to be ______ _______.

A

stratum intermedium

STRaight PIN IN

33
Q

CEOT is more common in which area of the jaws?

A

Posterior mandible 57%

posterior maxilla 21%

34
Q

CEOT is often associated with _______ and is most often found in adults age _____ years.

A

impacted teeth

40 years old

35
Q

Radiographically, CEOT can appear as radiopaque flecks with ill- or well-defined borders. This appearance is known as “______”

A

driven snow

36
Q

CEOT epithelial cells may be associated with homogenous material that stains as ______ or calcifications within the _______ that forms lamellated structures.

A

amyloid

amyloid!

37
Q

What are the term used to describe “calcifications within amyloid” associated with CEOT?

A

Liesgang Rings

38
Q

What is the treament for CEOT?

A

Conservative Excision with 15% recurrence (radical excision therefore isn’t warranted)