Tumor Supressors & Oncogenes Flashcards Preview

High Yield > Tumor Supressors & Oncogenes > Flashcards

Flashcards in Tumor Supressors & Oncogenes Deck (21)
Loading flashcards...
1
Q

abl

A

oncogene (CML. Gene product = tyrosine kinase receptor)

2
Q

APC

A

suppressor (FAP associated with familial colorectal cancer)

3
Q

bcl-2

A

Oncogene (causes Follicular lymphoma t;(14:18) and undifferentiated lymphomas.) (activated by c-myc and inhibits apoptosis by stabilizing mitchondrial membrane)

4
Q

BRAF

A

suppressor (causes melanoma and Papillary Thyroid cancer. Encodes RAF protein, which is downstream of RAS and controls gene expression)

5
Q

BRCA 1 and 2

A

supressors (products are DNA repair proteins)

6
Q

c-kit

A

oncogene (GIST [gastrointestinal stromal tumors]. Gene product = tyrosine kinase receptor)

7
Q

c-myc

A

Oncogene (causes Burkitt’s Lymphoma)

8
Q

DCC

A

suppressor (colon cancer)

9
Q

DPC4

A

suppressor (pancreatic cancer)

10
Q

HER2/neu (c-ERB2)

A

Oncogene (breast, ovarian, and gastric carcinomas. Gene product = a tyrosine kinase receptor)

11
Q

L-myc

A

Oncogene (causes lung cancer. Gene product = a transcription factor)

12
Q

NF-1

A

suppressor (encodes GAP protein, which normally constitutively inhibits RAS and therefore gene expression)

13
Q

NF-2

A

suppressor (gene product = Merlin (schwannomin) protein)

14
Q

N-myc

A

Oncogene (causes neuroblastoma. Gene product = a transcription factor)

15
Q

p16

A

suppressor (causes melanoma)

16
Q

p53

A

suppressor (causes Li Fraumeni Syndrome. Gene product = transcription factor, important for intrinsic pathway of apoptosis)

17
Q

PDGF-beta

A

oncogene (causes astrocytoma. It’s a growth factor, and therefore a ligand for tyrosine kinase receptors).

18
Q

ras

A

oncogene (colon cancer)

19
Q

Rb

A

suppressor (retinoblastoma, osteosarcoma. Supposed to inhibit E2F, blocking G1–>S phase.)

20
Q

ret

A

Oncogene (MEN2A and MEN2B syndromes)

21
Q

WT1

A

suppressor (causes Wilm’s tumor / nephroblastoma)