Tumor Suppressor Genes Flashcards Preview

Step 1 Basic Science > Tumor Suppressor Genes > Flashcards

Flashcards in Tumor Suppressor Genes Deck (15)
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1
Q

APC

A

-colorectal cancer

2
Q

BRCA1 / BRCA2

A
  • breast and ovarian cancer

- DNA repair problem

3
Q

DCC

A
  • colon cancer

- Deleted in Colon Cancer

4
Q

DPC4 / SMAD4

A
  • pancreatic cancer

- Deleted in Pancreatic Cancer

5
Q

MEN1

A
  • MEN1
  • Menin
  • 3P’s: Pituitary, Parathyroid, Pancreas
6
Q

NF1

A
  • NF1

- Ras GTPase activating protein

7
Q

NF2

A

-NF2

Merlin

8
Q

p16

A
  • Melanoma

- cyclin dependent kinase inhibitor 2A

9
Q

p53

A
  • pretty much all cancers
  • Li Fraumeni Syndrome
  • transcription factor that blocks G1-S
10
Q

Rb

A
  • Retinoblastoma, osteosarcoma

- Inhibits E2F, blocks G1-S phase

11
Q

PTEN

A

breast, prostate, endometrial cancer

12
Q

TSC1

A
  • Tuberous sclerosis

- Hamartin protein

13
Q

TSC2

A
  • Tuberous sclerosis

- tuberin protein

14
Q

VHL

A

-Von Hippel-Lindau disease, renal cell carcinoma

15
Q

WT1 / WT2

A

-Wilms Tumor, nephroblastoma