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Flashcards in Treatment of Cancer Drugs Deck (111)
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1

Mechlorethamine Class

Alkylating Agents

2

Mechlorethamine Use

Primary use: Hodgkin’s lymphoma, part of MOPP

3

Meclorethamine Pharmacokinetics/Dynamics

IV only—subQ slough/necrosis (often arterial suspply)

4

Mechlorethamine half-Life

Half life several minutesreacts rapidly

5

Mechlorethamine Adverse Effects

Vesicant, caustic to skin, mucous membranes
Acute—nausea/vomiting
Delayed—decreased blood counts, moderate w/ most doses
- 10-12 days after treatment
- Recovery 3-6 weeks

6

Cyclophosphamide Class

Alkylating Agent

7

Cyclophosphamide Use

widely used in leukemias and lymphomas

8

Cyclophosphamide Pharmacokinetics/dynamics

Oral or IV

9

Cyclophosphamide/Dynamics Activation

Pro-drug; activated by host metabolism (primarily liver)

10

Cyclophosphamide AE

Acute—nausea/vomiting
Delayed—bone marrow depression (moderate, dose-related)
- Alopecia
- Sterile hemorrhagic cystitis

11

Ifosfamide Class

Alkylating Agent

12

Ifosfamide Component of:

ICE (Ifosfamide, carboplatin, etoposide)

13

Ifosfamide Use

Hodgkin’s and non-Hodgkin’s lymphoma

14

Ifosfamide Analog of:

Cyclophosphamide

15

Ifosfamide Pharmacokinetics/dynamicss

IV only
high dose for bone marrow/stem cell rescue

16

Ifosfamide Adverse Effect

Acute—nausea and vomiting, urinary tract toxicity
More severe bone marrow depression than cyclophosphamide (Leukopenia)
Peripheral neuropathies
CNS effects—hallucinations, coma (may be due to chloroacetaldehyde)

17

Melphalan Use

Multiple Myeloma
Myeloablative therapy

18

Melphalan Class

Alkylating Agent

19

Melphalan pharmacokinetics/Dynamics

highly reactive
chem half life ~50 min
renal excretion

20

Melphalan AE

myelosuppression

21

Chlorambucil Class

Alkylating Agent

22

Chlorambucil kineticss/dynamicss

Oral once daily
Plasma half life~1.5 hours

23

Chlorambucil use

was primary drug for CLL but now rarely used

24

Bisulfan Class

Alkylating Agent

25

Bisulfan use

Key for CML prior to imatinib

26

Bisulfan kineticss/dynamics

Oral
IV high dose

27

Bisulfan AE

Profound myelosuppression
High dosepulm fibrosis
Hepatic veno-occlusive disease

28

Bendamustin Class

non-classic alkylating agent:
alkylates DNA but inhibits mitotic checkpoints

29

Bendamustin use

CLL
Indolent B-cell non-Hodgkin’s lymphoma

30

Bendamustine AE

Nausea vomiting
Myelosuppression
mucositis