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Flashcards in Tissue injury & repair Deck (8)
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1

What is tissue regeneration?

Growth of cells and tissue to replace lost structures
- complete reconstruction of superficial wounds, intact tissue framework
- tissues with high proliferative capacity eg. liver regeneration
true regeneration = bone following fracture, epithelium following injury

2

What 2 things make up tissue repair?

Combination of regeneration and scar formation
- deep wounds eg. myocardial infarction

3

Healing by scar formation
- what happens after severe tissue injury?

damage to parenchyma and stroma
Fibro-proliferative response:
- deposition of collagen and ECM components
Persistent damage = chronic inflammation = fibrosis

4

What is the sequence of healing?

Inflammation
Angiogenesis (growth of new blood vessels)
Migration & proliferation of parenchymal cells and fibroblasts
Scar formation
Connective tissue formation

5

Healing by first and secondary intention

First: edges of wounds near to each other eg. surgical wound sutured together
Secondary: edges of wound not close to each other eg. more granulation tissue

6

What are the local factors affecting wound healing?

Size, location type, infectious (foreign bodies delaying healing

7

What are the systemic factors affecting wound healing?

Nutritional status, metabolic status, circulatory/vascular status, hormones (glucocorticoids)

8

What are the 3 complications of tissue repair?

Deficient scar formation
Excessive repair
- excessive granulation tissue
- excessive collagen accumulation = hypertrophic scar
- KELOID
Formation of contractures