Thyroid Drugs (FA) Flashcards

1
Q

What are the drugs used in hyperthyroidism?

A

Methimazole, Propylthiouracil (PTU)

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2
Q

What is the common MoA of hyperthyroid drugs? What is unique about PTU?

A

Both block thyroid peroxidase, blocking oxidation and coupling of iodine
PTU also works on 5’-deiodinase, blocking peripheral T4 –> T3

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3
Q

What side toxicity is unique to PTU?

A

Hepatotoxicity

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4
Q

What hyperthyroid drug is used in pregnancy?

A

PTU in the first trimester

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5
Q

What drugs are used in hypothyroidism and their mechanism?

A

Levothyroxine, Triiodothyronine

Thyroxine replacement

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6
Q

What are the toxicities of hypothyroid drugs?

A

Induced hyperthyroidism: tachy, heat intolerance, tremors, arrhythmias

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