Flashcards in Thrombotic Disorders Deck (13)
What kind of clot is found in the arterial vs venous system?
Arterial = White clots (platelets & fibrin)
Venous = Red Clots (Fibrin & Red cells)
What causes venous vs arterial thrombi?
Arterial - Secondary to Atherosclerosis
Venous - Secondary to Stasis & Hypercoagulability
Risk factors for an arterial thrombosis?
How do we manage an arterial thrombus?
Primary prevention with lifestyle modification and treating the risk factors
Acutely: thrombolysis & Anti-platelets or Anti-coags
Risk factors for a DVT or PE?
What systemic diseases put you at risk of a DVT?
Autoimmune e.g. IBD, SLE or Anti-phospholipid syndrome
How can we test for a DVT/PE?
Pretest probability scoring (Well's or Geneva scores)
If probability score is low do a D-dimer
V/Q scan & CT Pulm Angiogram
How can we treat a DVT/PE?
Anticoagulants e.g. LMWH, Warfarin & DOACs
Thrombolysis only if massive PE
What are the commonest Heritable Thrombophilias?
Factor V Leiden
What's the major cause of microvascular Thrombus?
Disseminated Intravascular Coagulation (DIC)
What makes up microvascular thrombi?
Platelets &/or fibrin
What triggers DIC?