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Yr3 Haematology > Thrombotic Disorders > Flashcards

Flashcards in Thrombotic Disorders Deck (13)
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1

What kind of clot is found in the arterial vs venous system?

Arterial = White clots (platelets & fibrin)

Venous = Red Clots (Fibrin & Red cells)

2

What causes venous vs arterial thrombi?

Arterial - Secondary to Atherosclerosis

Venous - Secondary to Stasis & Hypercoagulability

3

Risk factors for an arterial thrombosis?

- Age
- Smoking
- Sedentary
- HTN
- DM
- Obesity
- Hypercholesterolaemia

4

How do we manage an arterial thrombus?

Primary prevention with lifestyle modification and treating the risk factors

Acutely: thrombolysis & Anti-platelets or Anti-coags

Secondary prevention

5

Risk factors for a DVT or PE?

Age
Surgery
Tissue Trauma
Immobility
Obesity
Pregnancy
Hormonal Therapy
FH
Systemis disease

6

What systemic diseases put you at risk of a DVT?

Cancers
Myeloproliferative Neoplasm
Autoimmune e.g. IBD, SLE or Anti-phospholipid syndrome

7

How can we test for a DVT/PE?

Pretest probability scoring (Well's or Geneva scores)
If probability score is low do a D-dimer

Doppler US

V/Q scan & CT Pulm Angiogram

8

How can we treat a DVT/PE?

Anticoagulants e.g. LMWH, Warfarin & DOACs

Thrombolysis only if massive PE

9

What are the commonest Heritable Thrombophilias?

Factor V Leiden

Prothrombin G20210A

10

What's the major cause of microvascular Thrombus?

Disseminated Intravascular Coagulation (DIC)

11

What makes up microvascular thrombi?

Platelets &/or fibrin

12

What triggers DIC?

Septicaemia
Malignancy
Eclampsia

13

What are the consequences of DIC?

Diffuse Tissue ischaemia --> Gangrene & Organ Failure

Consumes platelets/clotting factors --> Bleeding