The hypothalamus as a central regulator of metabolism Flashcards Preview

Modelling human disease and dysfunction > The hypothalamus as a central regulator of metabolism > Flashcards

Flashcards in The hypothalamus as a central regulator of metabolism Deck (8)
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1
Q

What is likely to be occurring in T2D in terms of the brain?

A

A disruption in the core homeostatic processes that are centrally governed by the brain

2
Q

What are the characteristics of mice lacking leptin (null animal)

A

obese
diabetic
infertile

3
Q

How do we know that leptin is having an effect on the brain?

A

Tissue specific knockouts of the leptin receptor in the brain

4
Q

What evidence is there that its the brain which mediates the majority of leptin’s actions ?

A
  1. deletion of leptin receptors in neurons induced obesity, re-expressing the leptin receptors in the knockdown mice ameliorated their obesity
  2. intracerebroventricular administration of leptin in leptin KD mice caused a reduction of body weight and food intake
5
Q

Which neurons are found in the Arcuate nucleus, and what is their function?

A

Neuropeptide Y and agouti-related peptide neurons- stimulate food intake
POMC neurons- reduce food intake

6
Q

What does leptin do to the 2 main neuron groups in the Arc nucleus?

A
  1. Inhibit N.peptide y

2. Stimulate POMC neurons

7
Q

What do we not yet know about T2D and the hypothalamus?

A

How deficient activity of hypothalamic neurons leads to T2D and obesity

8
Q

What is the model for the ‘hypothalamic regulation of hepatic glucose production’?

A

Leptin sensing neurons in the ARC receive input on energy stores-> increased hepatic vagal tone to the liver -> increases hepatic insulin selectivity