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Flashcards in TERMS Deck (11)
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1
Q

what is this anti fungal?

inhibition of cyp450 12 alpha demethylase which inhibits conversion of lanosterol into ergosterol

A

azoles

-zole

2
Q

what is this antifungal?

inhibits beta 1,3-D-glucan synthase leading to disruption of cell wall integrity and then death

A

echinocandins

-fungin

3
Q

what is this anti fungal?

binds to ergosterol in the fungal membrane leading to pores made in the membrane then to leakage of cell contents and then death

A

polyene

-amphotericin

4
Q

this amphotericin drug?

gets converted to 5-fluorouracil in the fungal cell leading to further conversion to metabolite that interferes with protein/DNA synthesis

A

flucytosine

5
Q

name this topical azole?

onychomycosis(trichophytan rubrum/mentagorphytes)

A

efinaconazole

6
Q

name this topical azole?

lozenge (oropharyngeal candidiasis/thrush)
cream (vulvovaginal candidiasis and all tinea)

A

clotrimazole

7
Q

name this topical azole?

tablet (thrush)
cream (vulvovaginal candidiasis)
cream/ointment/aerosol/e tab

A

miconazole

8
Q

name this topical azole?

cream/foam/gel/shampoo (cutaneous candidiasis, dandruff, seborrheic dermatitis, tinea)

A

ketoconazole

9
Q

Misc anti fungal?

Mechanism – inhibits squalene epoxidase, a key enzyme in ergosterol synthesis → cell death

▪ Clinical uses – tinea, onychomycosis

A

Terbinafine

10
Q

Misc anti fungal?

Mechanism – inhibits fungal cell mitosis at metaphase; binds to human keratin making it resistant to fungal invasion
• Fungistatic

Clinical uses – tinea and onychomycosis

A

Griseofulvin (oral only)

11
Q

Misc anti fungal?

Mechanism – inhibits transport of essential elements (especially trivalent metal cations) of the fungal cell
• Disrupts the synthesis of DNA, RNA and protein

▪ Clinical Uses – Tinea, cutaneous candidiasis, seborrheic dermatitis, onychomycosis

A

Ciclopirox

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