Flashcards in T helper cell subsets Deck (87)
How are the Th subsets defined?
by the different combinations of cytokines that they secrete
what is the function of follicular helper T cells?
interact with naive B cells through linked recognition of antigen and traffic to B cell follicles where they promote the germinal center responses
What chemokine receptor do Tfh cells express?
what does the term antigen experienced mean?
has already seen the antigen (probably from dendritic cell)
What cytokines direct the development of Tfh cells?
What transciption factor is important for Tfh cells?
why is Bcl6 important for Tfh cells?
required for the expression of CXCR5
What is the receptor CXCR5 for?
chemokine CXCL13 produced by stromal cells of the B cell follicle
What cytokine do Tfh cells make a lot of?
What is hte function of IL-21 produced by Tfh cells?
supports the proliferation and differentiation of B cells into plasma cells and supports development of Tfh cells
What types of cytokines do Tfh cells produce?
all three types- direct type of antibody production
What does IFNy produced by Tfh cause?
activate B cells to produce strongly opsonising antibodies- IgG1 and IgG3
What does IL-4 produced by Tfh cause?
B cells to differentiate and tomake IgE
What is the function of IL-17 produced by Tfh cells?
generating opsonising antibodies against extracellular pathogens in the context of type 3/Th17 responses
What transcription factor does IL-21 induce in B cells and T cells ?
What is the function of STAT3?
supports proliferation and differentiation
What ligand do activated B cells express which stimulates complete differentiation of Tfh cells?
What is the function of ICOS signaling?
induces Bcl-6 and c-Maf transciption factors
what is the function of Bcl-6 and c-Maf transcription factors?
SAP production (required for sustained contact between B and Tfh cells )
What interaction is critical for CD4 help with CD8 cells?
What technical advances in the 1980s allowed the progress of cellular immunology?
ability to clone T cells and cytokine assays
What are the important cytokines produced by Th1 cells?
IL-2 and IFNy
What are the important cytokines produced by Th2 cells?
IL-4 and IL-5
What are the effects of Th1 IFNy?
IgG2a; macrophage activation; delayed hypersensitivity
what are hte effects of Il-3; Il-4; IL-5 and IL-13 produced by Th2 cells?
IgE; mast cells ; eosinophils stimulation
What cytokines produced by Th2 cells inhibit Th1?
IL-4 and IL-10
What are clones which produce both type 1 and type 2 cytokines called?
What is the function of Th1 cells?
eradicate infections by microbes that can survive or replicate within macrophages
When is Th1 development induced?
IFNy and IL-12