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Flashcards in T helper cell subsets Deck (87)
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1

How are the Th subsets defined?

by the different combinations of cytokines that they secrete

2

what is the function of follicular helper T cells?

interact with naive B cells through linked recognition of antigen and traffic to B cell follicles where they promote the germinal center responses

3

What chemokine receptor do Tfh cells express?

CXCR5

4

what does the term antigen experienced mean?

has already seen the antigen (probably from dendritic cell)

5

What cytokines direct the development of Tfh cells?

IL-6; IL-21

6

What transciption factor is important for Tfh cells?

Bcl6

7

why is Bcl6 important for Tfh cells?

required for the expression of CXCR5

8

What is the receptor CXCR5 for?

chemokine CXCL13 produced by stromal cells of the B cell follicle

9

What cytokine do Tfh cells make a lot of?

IL-21

10

What is hte function of IL-21 produced by Tfh cells?

supports the proliferation and differentiation of B cells into plasma cells and supports development of Tfh cells

11

What types of cytokines do Tfh cells produce?

all three types- direct type of antibody production

12

What does IFNy produced by Tfh cause?

activate B cells to produce strongly opsonising antibodies- IgG1 and IgG3

13

What does IL-4 produced by Tfh cause?

B cells to differentiate and tomake IgE

14

What is the function of IL-17 produced by Tfh cells?

generating opsonising antibodies against extracellular pathogens in the context of type 3/Th17 responses

15

What transcription factor does IL-21 induce in B cells and T cells ?

STAT3

16

What is the function of STAT3?

supports proliferation and differentiation

17

What ligand do activated B cells express which stimulates complete differentiation of Tfh cells?

ICOSL

18

What is the function of ICOS signaling?

induces Bcl-6 and c-Maf transciption factors

19

what is the function of Bcl-6 and c-Maf transcription factors?

SAP production (required for sustained contact between B and Tfh cells )

20

What interaction is critical for CD4 help with CD8 cells?

CD40:CD40L interaction

21

What technical advances in the 1980s allowed the progress of cellular immunology?

ability to clone T cells and cytokine assays

22

What are the important cytokines produced by Th1 cells?

IL-2 and IFNy

23

What are the important cytokines produced by Th2 cells?

IL-4 and IL-5

24

What are the effects of Th1 IFNy?

IgG2a; macrophage activation; delayed hypersensitivity

25

what are hte effects of Il-3; Il-4; IL-5 and IL-13 produced by Th2 cells?

IgE; mast cells ; eosinophils stimulation

26

What cytokines produced by Th2 cells inhibit Th1?

IL-4 and IL-10

27

What are clones which produce both type 1 and type 2 cytokines called?

Th0 cells

28

What is the function of Th1 cells?

eradicate infections by microbes that can survive or replicate within macrophages

29

When is Th1 development induced?

IFNy and IL-12

30

What are type 1 interferons?

IFNa and IFNb