T helper cell subsets Flashcards Preview

Basic Immunology- Module 1 > T helper cell subsets > Flashcards

Flashcards in T helper cell subsets Deck (17)
Loading flashcards...
1

What is the function of follicular helper T cells?

help B cells

2

What is expressed on Tfh cells?

CXCR5- chemokine receptor

3

Where are Tfh cells found?

in B cell follicles of secondary lymphoid organs

4

What cytokines do Tfh cells produce?

IL2; IL4; IL21 and IFNy

5

What is a special feature of Tfh cells?

antigen experienced- have already seen the antigen before from probably a DC

6

What is the function of IL-21 secreted by Tfh cells?

stimulate the formation of Tfh cells as well as B cells

7

What interaction is critical for CD4+ T cell help to cytotoxic T cells?

CD40:CD40L - between APC and Th or Th and CD8- probably both

8

What cytokines do Th1 cells produce?

IL-2 and IFNy

9

What cytokines do Th2 cells produce?

IL-4; IL-5; IL-10; IL-13

10

What do Th2 cells stimulate?

IgE; mast cells; eosinophils

11

What do Th1 cells stimulate?

IgG2a; macrophage activation; delayed hypersensitivity

12

What are Th cells which produce both type 1 and type 2 cytokines?

Th0 cells

13

What is polarisation?

development of Th1 or Th2 from a T-cell precursor

14

What cytokine drives the polarisation to Th1 /

IL12

15

What cytokine drives the polarisation to a Th2?

IL-4

16

What transcription factors drive the polarisation to a Th1?

STAT4 and T-bet

17

What transcription factors drive the polarisation of Th cells to Th2?

STAT6 and GATA3