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Flashcards in Stimulants Deck (6)
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1
Q

What is the mechanism of action of amphetamine/Adderall

A

Increases presynaptic release of Dopamine, NE, & Serotonin through a reversal of normal operation of neuronal reuptake processing, causing increased catecholamines in synapse
- twice as potent as methylphenidate

2
Q

What is the mechanism of action of methylphenidate (Ritalin, Metadate, Concerta)?

A

Inhibits synaptic reuptake of catecholamnines

3
Q

What are the side effects of stimulants?

A
  • Insomnia, HA, worsen tremor/tics
  • Weight loss
  • CVS overstimulation (HTN, tachycardia)
  • Paranoid ideation/psychosis
4
Q

What is the mechanism of action/indication for amoxetine/strattera?

A
  • Norepinephrine reuptake inhibitor (NRI) and non-stimulant stimulant treatment for ADHD with co-morbid anxiety or depression
5
Q

What is the mechanism of action/indication for modafinil/provigil?

A
  • Non-stimulant but selective NE and Dopamine blocker (NDRI)
  • Used to improve wakefulness related to narcolepsy and obstructive sleep apnea and to treat daytime fatigue associated with depression and multiple sclerosis
6
Q

What is the mechanism of action/indication for clonadine/catapres?

A
  • Alpha (α2) adrenergic agonist used to tx HTN

- Anxiolytic, ADHD, Tourette’s syndrome, PTSD (nightmares), Opiate withdrawal