Flashcards in Stimulants Deck (6)
Loading flashcards...
1
Q
What is the mechanism of action of amphetamine/Adderall
A
Increases presynaptic release of Dopamine, NE, & Serotonin through a reversal of normal operation of neuronal reuptake processing, causing increased catecholamines in synapse
- twice as potent as methylphenidate
2
Q
What is the mechanism of action of methylphenidate (Ritalin, Metadate, Concerta)?
A
Inhibits synaptic reuptake of catecholamnines
3
Q
What are the side effects of stimulants?
A
- Insomnia, HA, worsen tremor/tics
- Weight loss
- CVS overstimulation (HTN, tachycardia)
- Paranoid ideation/psychosis
4
Q
What is the mechanism of action/indication for amoxetine/strattera?
A
- Norepinephrine reuptake inhibitor (NRI) and non-stimulant stimulant treatment for ADHD with co-morbid anxiety or depression
5
Q
What is the mechanism of action/indication for modafinil/provigil?
A
- Non-stimulant but selective NE and Dopamine blocker (NDRI)
- Used to improve wakefulness related to narcolepsy and obstructive sleep apnea and to treat daytime fatigue associated with depression and multiple sclerosis
6
Q
What is the mechanism of action/indication for clonadine/catapres?
A
- Alpha (α2) adrenergic agonist used to tx HTN
- Anxiolytic, ADHD, Tourette’s syndrome, PTSD (nightmares), Opiate withdrawal