Spasmolytics - centrally acting skeletal muscle relaxants. Flashcards Preview

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Flashcards in Spasmolytics - centrally acting skeletal muscle relaxants. Deck (9)
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1
Q

Mechanism of the spasmolytics

A

Usually acting in the CNS

Reduce abnormally elevated tone of the muscles caused by neurologic disorders or muscle end plate disease.

2
Q

What is spasticity

A

Increased tonic muscle contraction, spasms, and increased stretch reflexes.

3
Q

List the CNS spasmolytics

9

A

BBCCCTTG

Baclofen

Benzos - Diazepam

CycloBENZaprine

Chlorzoxazone

Carisoprodol

Tizanidine

Tolperisone

Guaifenesin

and Dantrolene

4
Q

Causes of spasticity

A

SCI
Multiple sclerosis
Strokes
Developmental CNS disorders, cerebral palsy

5
Q

Spasmolytics for chronic use

A

Baclofen, Diazepam, Tizanidine

and Dantrolene

6
Q

Acute use spasmolytics

What are they typically used to treat?

A

Guaifenesin
Cyclobenzaprine
Chlorzoxazone
and Dantrolene

Acute muscle injury
They are all totally useless at treating CNS caused spasticity, like SCI or cerebral palsy. (except dantrolene)

7
Q

Cyclobenzaprine side effects

A

Marked sedation
Antimuscarinic effects
Visual halluciantions

8
Q

Dantrolene MoA

A

Binds toe the RyR1 receptor. Ryanodine receptor in the Sarcoplasmic reticulum. Decreases Ca++ release.

9
Q

What causes malignant hyperthermia

A

Most common are the volatile anesthetic gases,
Halothane, sevoflurane, desflurane, isoflurane, enflurane

Also by depolarizing muscle relaxants
Suxamethonium and Decamethonium.

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