Small Group: Lipids and Obesity Cases Flashcards Preview

MS2 - Digestive, Endocrine, and Metabolic Systems > Small Group: Lipids and Obesity Cases > Flashcards

Flashcards in Small Group: Lipids and Obesity Cases Deck (10)
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1
Q

What are the four categories of people who have been shown to benefit from statins?

A
  • History of ASCVD
  • Age 40-75 with diabetes; LDL greater than 70
  • Age 40-75 with 10-year risk of CVD greater than 7.5%; LDL greater than 70
  • LDL greater than 190
2
Q

What is combined dyslipidemia?

A

It can be familial dysbetalipoproteinemia (if the triglycerides and total cholesterol are extremely high), or it can be a non-specific, polygenic disorder.

3
Q

How do fibrates work?

A

Fibrates, such as gemfibrozil, stimulate lipoprotein lipase (“FIBbing makes you a LIar”). Thus, they break down VLDL and raise HDL.

4
Q

What medication can raise triglyceride levels?

A

Estrogen

5
Q

What are five things that can increase triglyceride levels?

A
  • Estrogen
  • Alcohol
  • T2DM (poorly controlled)
  • Renal failure
  • Hypothyroidism
6
Q

What is apoC2?

A

It is a ligand on apolipoprotein B100 that binds to lipoprotein lipase. Without it, patients will have hypertriglyceridemia.

7
Q

Of hypertension, obesity, and dyslipidemia, which has the strongest correlation with insulin resistance?

A

Hypertension

8
Q

A 500 kcal deficit per day is equal to one pound ________.

A

per week

9
Q

Describe familial dysbetalipoproteinemia.

A

A mutation in apoE2 leads to failure of VLDL, IDL, LDL, and chylomicrons to be reabsorbed by the liver and subsequently triglyceride and cholesterol levels will rise.

10
Q

Triglyceride levels over _______ should be treated to prevent pancreatitis.

A

500

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