SLE, Vasculitis, and Myositis Flashcards Preview

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Flashcards in SLE, Vasculitis, and Myositis Deck (27)
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1
Q

_____ shows endomysial distribution invading non-necrotic fibers, consisting primarily of _____ cell infiltrate

A

Polymyositis; CTL

2
Q

_____ shows perivascular distribution of inflammatory infiltrate around the periphery of fascicles, consisting of ______ cells.

A

CD4 T cell, B cells, macrophages, dendritic cells

3
Q

_______ is an antibody against ________ associated with microscopic polyangiitis (MPA).

A

Perinuclear ANCA; Myeloperoxidase (MPO)

4
Q

_______ is an antibody against proteinase-3 (PR3) in ________.

A

Cytoplasmic ANCA (c-ANCA); Granulomatosis with Polyangiitis (Wegener’s)

5
Q

________ is an antibody against ________ in Granulomatosis with Polyangiitis (Wegener’s).

A

Cytoplasmic ANCA (c-ANCA); proteinase-3 (PR3)

6
Q

________ is an antibody against Myeloperoxidase (MPO) associated with _______.

A

Perinuclear ANCA; microscopic polyangiitis (MPA)

7
Q

Anti-synthetase syndrome most commonly presents with ______.

A

Interstitial lung disease

8
Q

Antibodies in SLE include _____ (3)

A

Anti-RBC, Anti-WBC, Anti-Phospholipid (aPL)

9
Q

Antibodies in SLE may be directed against ______ (3)

A

Anti-dsDNA, Anti-histone, Antibodies to non-DNA non-histone nuclear antigens

10
Q

Cytoplasmic ANCA (c-ANCA) is an antibody against _________ in __________.

A

proteinase-3 (PR3); Granulomatosis with Polyangiitis (Wegener’s)

11
Q

Evidence suggests that the etiology of dermatomyositis and polymyositis is _____

A

Viral infection

12
Q

In SLE, >95% of paitents have these antibodies: ____

A

ANA

13
Q

In SLE, antibody responses to autoantigens require ______ cells.

A

CD4+ T cells

14
Q

In SLE, immune complex-mediated disease is caused by _______ immune complexes.

A

Anti-dsDNA-DNA

15
Q

In vasculitis, endothelial cell injury is mediated by ___ cells.

A

T

16
Q

Large Vessel Arteritis (2)

A

Giant Cell Arteritis, Takayasu Arteritis

17
Q

Medium Vessel Arteritis (2)

A

Polyarteritis nodosa, Kawasaki disease

18
Q

Perinuclear ANCA is an antibody against ________ associated with ________.

A

Myeloperoxidase (MPO); microscopic polyangiitis (MPA)

19
Q

Skin changes in dermatomyositis (5)

A

Gottron’s Nodules, Heliotrope rash, Shawl sign/V-sign, Mechanic’s hands, Periungal changes/erythema

20
Q

SLE has greatest genetic association with the ______ allele (also some with the ______ allele)

A

C4A null; HLA-DR3

21
Q

SLE immunofluorescence staining of the glomerulus shows a ______ pattern

A

Lumpy-bumpy

22
Q

SLE is caused by Type ___ Immunopathology.

A

II and III

23
Q

SLE is more common in ____ (sex).

A

Women

24
Q

SLE results from a misdirected recognition of self as foreign, resulting in _____ cell autoimmune processes.

A

T and B

25
Q

Small Vessel Arteritis - ANCA(-) (3)

A

Henoch-Schonlein Purpura, Essential Cryoglobulinemic Vasculitis, Cutaneous Leukocytoclastic angiitis

26
Q

Small Vessel Arteritis - ANCA(+) (3)

A

Wegener’s Granulomatosis/Granulomatosis with Polyangiitis, Eosinophilic Granuloma with Polyangiitis/Churg-Strauss Syndrome, Microscopic Polyangiitis

27
Q

The most common anti-synthetase antibody, _____, targets _______.

A

Anti-Jo1; histidyl-tRNA synthetase