Flashcards in SLE, Vasculitis, and Myositis Deck (27)
_____ shows endomysial distribution invading non-necrotic fibers, consisting primarily of _____ cell infiltrate
_____ shows perivascular distribution of inflammatory infiltrate around the periphery of fascicles, consisting of ______ cells.
CD4 T cell, B cells, macrophages, dendritic cells
_______ is an antibody against ________ associated with microscopic polyangiitis (MPA).
Perinuclear ANCA; Myeloperoxidase (MPO)
_______ is an antibody against proteinase-3 (PR3) in ________.
Cytoplasmic ANCA (c-ANCA); Granulomatosis with Polyangiitis (Wegener's)
________ is an antibody against ________ in Granulomatosis with Polyangiitis (Wegener's).
Cytoplasmic ANCA (c-ANCA); proteinase-3 (PR3)
________ is an antibody against Myeloperoxidase (MPO) associated with _______.
Perinuclear ANCA; microscopic polyangiitis (MPA)
Anti-synthetase syndrome most commonly presents with ______.
Interstitial lung disease
Antibodies in SLE include _____ (3)
Anti-RBC, Anti-WBC, Anti-Phospholipid (aPL)
Antibodies in SLE may be directed against ______ (3)
Anti-dsDNA, Anti-histone, Antibodies to non-DNA non-histone nuclear antigens
Cytoplasmic ANCA (c-ANCA) is an antibody against _________ in __________.
proteinase-3 (PR3); Granulomatosis with Polyangiitis (Wegener's)
Evidence suggests that the etiology of dermatomyositis and polymyositis is _____
In SLE, >95% of paitents have these antibodies: ____
In SLE, antibody responses to autoantigens require ______ cells.
CD4+ T cells
In SLE, immune complex-mediated disease is caused by _______ immune complexes.
In vasculitis, endothelial cell injury is mediated by ___ cells.
Large Vessel Arteritis (2)
Giant Cell Arteritis, Takayasu Arteritis
Medium Vessel Arteritis (2)
Polyarteritis nodosa, Kawasaki disease
Perinuclear ANCA is an antibody against ________ associated with ________.
Myeloperoxidase (MPO); microscopic polyangiitis (MPA)
Skin changes in dermatomyositis (5)
Gottron's Nodules, Heliotrope rash, Shawl sign/V-sign, Mechanic's hands, Periungal changes/erythema
SLE has greatest genetic association with the ______ allele (also some with the ______ allele)
C4A null; HLA-DR3
SLE immunofluorescence staining of the glomerulus shows a ______ pattern
SLE is caused by Type ___ Immunopathology.
II and III
SLE is more common in ____ (sex).
SLE results from a misdirected recognition of self as foreign, resulting in _____ cell autoimmune processes.
T and B
Small Vessel Arteritis - ANCA(-) (3)
Henoch-Schonlein Purpura, Essential Cryoglobulinemic Vasculitis, Cutaneous Leukocytoclastic angiitis
Small Vessel Arteritis - ANCA(+) (3)
Wegener's Granulomatosis/Granulomatosis with Polyangiitis, Eosinophilic Granuloma with Polyangiitis/Churg-Strauss Syndrome, Microscopic Polyangiitis