SLE, Vasculitis, and Myositis Flashcards Preview

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Flashcards in SLE, Vasculitis, and Myositis Deck (27)
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1

_____ shows endomysial distribution invading non-necrotic fibers, consisting primarily of _____ cell infiltrate

Polymyositis; CTL

2

_____ shows perivascular distribution of inflammatory infiltrate around the periphery of fascicles, consisting of ______ cells.

CD4 T cell, B cells, macrophages, dendritic cells

3

_______ is an antibody against ________ associated with microscopic polyangiitis (MPA).

Perinuclear ANCA; Myeloperoxidase (MPO)

4

_______ is an antibody against proteinase-3 (PR3) in ________.

Cytoplasmic ANCA (c-ANCA); Granulomatosis with Polyangiitis (Wegener's)

5

________ is an antibody against ________ in Granulomatosis with Polyangiitis (Wegener's).

Cytoplasmic ANCA (c-ANCA); proteinase-3 (PR3)

6

________ is an antibody against Myeloperoxidase (MPO) associated with _______.

Perinuclear ANCA; microscopic polyangiitis (MPA)

7

Anti-synthetase syndrome most commonly presents with ______.

Interstitial lung disease

8

Antibodies in SLE include _____ (3)

Anti-RBC, Anti-WBC, Anti-Phospholipid (aPL)

9

Antibodies in SLE may be directed against ______ (3)

Anti-dsDNA, Anti-histone, Antibodies to non-DNA non-histone nuclear antigens

10

Cytoplasmic ANCA (c-ANCA) is an antibody against _________ in __________.

proteinase-3 (PR3); Granulomatosis with Polyangiitis (Wegener's)

11

Evidence suggests that the etiology of dermatomyositis and polymyositis is _____

Viral infection

12

In SLE, >95% of paitents have these antibodies: ____

ANA

13

In SLE, antibody responses to autoantigens require ______ cells.

CD4+ T cells

14

In SLE, immune complex-mediated disease is caused by _______ immune complexes.

Anti-dsDNA-DNA

15

In vasculitis, endothelial cell injury is mediated by ___ cells.

T

16

Large Vessel Arteritis (2)

Giant Cell Arteritis, Takayasu Arteritis

17

Medium Vessel Arteritis (2)

Polyarteritis nodosa, Kawasaki disease

18

Perinuclear ANCA is an antibody against ________ associated with ________.

Myeloperoxidase (MPO); microscopic polyangiitis (MPA)

19

Skin changes in dermatomyositis (5)

Gottron's Nodules, Heliotrope rash, Shawl sign/V-sign, Mechanic's hands, Periungal changes/erythema

20

SLE has greatest genetic association with the ______ allele (also some with the ______ allele)

C4A null; HLA-DR3

21

SLE immunofluorescence staining of the glomerulus shows a ______ pattern

Lumpy-bumpy

22

SLE is caused by Type ___ Immunopathology.

II and III

23

SLE is more common in ____ (sex).

Women

24

SLE results from a misdirected recognition of self as foreign, resulting in _____ cell autoimmune processes.

T and B

25

Small Vessel Arteritis - ANCA(-) (3)

Henoch-Schonlein Purpura, Essential Cryoglobulinemic Vasculitis, Cutaneous Leukocytoclastic angiitis

26

Small Vessel Arteritis - ANCA(+) (3)

Wegener's Granulomatosis/Granulomatosis with Polyangiitis, Eosinophilic Granuloma with Polyangiitis/Churg-Strauss Syndrome, Microscopic Polyangiitis

27

The most common anti-synthetase antibody, _____, targets _______.

Anti-Jo1; histidyl-tRNA synthetase