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Flashcards in Skeletal Deck (17)
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1
Q

Name the Spasmolytics /Antispasmodics

  • Chronic CNS actions (4)
  • Chronic Muscle Action (2)
  • Acute Use (1)
A
  • Baclofen, Diazepam, Tizandine, Cyclobenzaprine
  • Dantrolene, Botulism
  • Cyclobenzaprine
2
Q

Spasmolytics treat 2 conditions
• Spasticity from _____ motor neuron lesions (spasmolytics)
Spasms from _______ musculoskeletal condtitions

A
  • Upper

* Peripheral

3
Q

What is the site of Spasmolytic action?

A

GABA receptors

4
Q

• Which medication is centrally acting, inhibits spinal motor neurons by decreasing excitatory trasnmitters?

A

• Baclofen - GABA receptor for pain

5
Q

• What is the use of Baclofen?

A

Severe spasticity from Cerebral palsy, multiple sclerosis, or Stroke

6
Q

• Which medication is a central acting, is a GABA enhancer, and causes Central sedation and inhibits primary motor afferent in spinal cords

A

• Diazepam

7
Q
  • What is Diazepam used for?
  • Where is Diazepam metabolized
  • What are adverse effects of Diazepam
A
  • Spasm from MS, CVA, ALS
  • Liver = Hepatic metabolism
  • Sedation, Antegrade amnesia, Addictive
8
Q
  • What drug inhibits motor reflex outputs, is an Alpha 2 Agonist in the spinal cord
  • Is used to treat MS, CVAs, and ALS
A

• Tizanidine

9
Q
  • Where is Tizanidine metabolized.

* What are Tizanidine’s 3 ADEs?

A
  • Renal and Hepatic elimination.

* (SHoW) Sedation, HoTN, Weakness

10
Q
  • What is Cyclobenzaprine used for?
  • Where is Cyclobenzaprine metabolized
  • What are adverse effects of Cyclobenzaprine
A
  • Only Acute spasms from muscle injury or inflammation
  • Hepatic metabolism
  • Strong Antimuscarinic = Dumb as a bitch + ocular effects
11
Q

• What are the antispasmodic drugs?

CCOMM

A
(CCOMM)
• Carisoprodol (Soma)
• Chlorzoxazone
• Orphenadrine
• Metazalone
• Methocarbamol
12
Q

What do the Antispasmodics?

A

• Acute muscle spams relief

13
Q
  • What is Carisoprodol drug classification? (Car ->Mepro -> extensive withdrawal sxs)
  • How can you limit these sxs?
A
  • Schedule IV: metabolized to meprobamate (another Class IV) which is a central muscle relaxant.
  • Taper over 14 days
14
Q

• What drug blocks RyR1 Ca channels in the sacroplasmic reticulum in skeletal muscle, and Weakens muscle contraction due to few myosin-actin

A

• Dantrolene

15
Q

• What is Dantrolene used for?

A
  • Malignant Hyperthermia (IV)

* Spasm due to Cerebral Palsy, SCI, MS

16
Q

• What is botulism used for?

A

• Cleaves fusion proteins in nerve ending = Flaccid paralysis

17
Q

• F/T: Botulism is used for cerebral palsy spasm, MS, Overactive bladder, Migraine?

A

True