Signaling pathways Flashcards Preview

FA notes > Signaling pathways > Flashcards

Flashcards in Signaling pathways Deck (66)
Loading flashcards...
1

cAMP

FLAT ChAMP
FSH, LH, ACTH, TSH
CRH, hCG, ADH (V2 receptor), MSH, PTH
calcintonin
GHRH
glucagon
PAF

2

cGMP

ANP
NO (EDRF)

3

IP3

GnRH, GHRG(minor)
Oxytocin
ADH (V1 receptor)
TRH
Histamin (H1)
Angiotensin II
Gastrin

4

Steroid receptor

Vitamin D
Estrogen
Testosterone
T3/T4
Cortisol
Aldosterone
Progesterone

5

Instrinsic tyrosine kinase

Insulin
IGF-1
FGF
PDGF
EGF

6

What pathway do instrinsic tyrosine kinases utilize?

MAP kinase pathway

7

Receptor assoc tyrosine kinases

Prolactin
Immunomodulators: cytokines IL-2, IL-6, IL-8, IFN
GH

8

What pathway do receptor assoc tyrposine kinases utilize?

JAK/STAT pathway

9

How does T3 increase CO?

binds to B1 receptors on the heart

10

how does T3/T4 increase BMR?

increase Na/K ATPase

11

What do you see elevated in the urine of a child w adrenal neuroblastoma?

HVA: homovanilic acid, a breakdown product of DA

12

what is the genetic mutation is neuroblastoma and what is the tumor marker>

overexpression of N-myc oncogene > rapid tumor progression
- tumor marker = Bombesin
- neurofilament stain

13

people with Hashimotos thyroiditis have an increased risk of what cancer?

Non-hodgkins lymphoma

14

very tender thyroid, increased ESR

subacute thyroiditis: self limited hypothyroidism often following a flu like illness
- see granulomatous inflammation on histo

15

fixed, rock hard and painless goider

Reidels thyroiditis: thyroid replaced by fibrous tissue

16

Jod-Basedow phenomenon- what is it? what can cause it?

when someone with iodine deficiecny is given iodine> hyyperthyroidism!
- seen when given contrast radio-iodine or amiodarone

17

what is the cause of death in thyroid storm?

death by arrhythmia

18

thyroid cancer w empty appearing nuclei, psammoma bodies, whats the cancer and assoc gene?

- Papillary carcnoma
- Ret gene mutation

19

thyroid cancer that produces calcitonin, sheets of cells in amyloid stroma, what is it and what is gene and associations?

- Medullary carcinoma
- ret gene mutation, assoc with MEN 2A and 2B

20

When do you see psammoma bodies? 4 instances

Papillary carcinoma of thyroid
Serous cystadenocarcinoma of the ovary
Meningioma
Mesotheliam
(PSMM)

21

hypocalcemia, shortened 4th/5th digits, short stature

Pseudohypoparathyrodism: Albright's hereditary osteodystrophy
- AD kidney unresponsive to PTH

22

how do you diagnose Acromegaly?

- increase serum IGF-1
- failure to suppress serum GH following oral glucose tolerance test

23

what inhibits the release of GH?

glucose and somatostatin

24

What are the treatments for Nephrogenic diabetes insipidus?

- Hydrochlorothiazide
- Indomethacin
- Amiloride

25

What drugs can casue secondary nephrogenic DI?

-Lithium
- Demeclocycline
- Hypercalcemia

26

What drug can cause SIADH?

Cyclophosphamide

27

Treatment of SIADH?

- Demeclocycline
- Conivaptan
-Tolvaptan

28

how do you treat carcinoid syndrome?

somatostatin analog = Octreotide

29

what is the inheritance of MEN syndromes?

autosomal dominant

30

What amino acids stimulate the release of gastrin?

1. Phenylalanine
2. Tryptophan