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ANPH 500 - Pharmacology - McCarver > Sevoflurane > Flashcards

Flashcards in Sevoflurane Deck (47)
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0

Is sevo a methyl isopropyl ether or a methyl ethyl ether?

Methyl isopropyl ether

1

No more than __ carbon atoms, non flammable, and stable to soda lime

Four

2

Fully halogenated compounds are usually __ anesthetics and convulsants

Poor

3

Metabolism rate of sevo

3-5%

4

Blood gas partition coefficient of sevo

0.69

5

Sevo is __ an airway irritant

Not really
Can do a one breath sevo induction

6

How many fluorine atoms on sevo?

Seven

7

Des is synthesized from __

ISO

8

Mac of sevo

2.1%

9

Addition of nitrous __ mac of sevo

Decreases

10

Mac awake __

0.3 x mac (2.1)

11

Mac BAR

1.5x mac

12

Mac intubation

2x mac

13

Hypothermia, increased age, benzo, opiates, alpha2 agonists, nitrous, pregnancy, acute ethanol, sick, hypoNA, hyperMag
All __ mac

Decrease

14

CNS catecholamine stim, chronic ethanol, hyperNa
All __ mac

Increase

15

The lower the BGPC, the __ alveolar conc equilibrates to arterial conc

Quicker

16

Low solubility of sevo facilitates __ lung elimination

Rapid

17

Sevo vapor pressure

160 mmHg

18

Increased ventilation = __ equilibration

Quicker

19

Increased cardiac output = __ equilibration

Slower

20

Sevo could equilibrate in __ minutes in the vessel rich group

4-8

21

Can sevo provide retrograde amnesia or long term impairment of intellectual function?

NO

22

Sevo __ reduce cerebral metabolic oxygen requirements

Will

23

Sevo has the potential to increase ICP in patients with space occupying lesions not receiving hyperventilation.

Slide 37
It is a cerebral blood vessel dilator
Treat by hyperventilate to end tidal CO2 around 30

24

Around 2 mac you may have an __ EEG

Isoelectric

25

Sevo does not produce seizures and can actually __ seizure activity

Suppress

26

Sevo increases cerebral blood flow for up to __ hours

Four

27

Hyperventilate to an end tidal CO2 of __ to counteract increased cerebral blow flow

30

28

Sevo iso des ALL lower BP by decreasing __

SVR

29

Sevo __ delivery of NMB

Enhances