REVIEW 5 (pulm)

Question 1

Which 2 cancers are most likely to be dx by cytology b/c they are most likely centrally located?

Answer 1

1. Squamous Cell Carcinoma
2. Small Cell Carcinoma

Question 2

What type of lung cancer is the only tumor that is sensitive to radiotherapy and chemotherapy?

Answer 2

Small Cell Carcinoma

Question 3

What is the old term for small cell carcinoma?

Answer 3

Oat-cell Carcinomas

Question 4

What is the old term for adenocarcinoma (carcinoma of the lung)

Answer 4

“Scar Carcinoma”

Question 5

Which lung cancer produces hormones?

Answer 5

Small cell carcinoma

(tumor of neuroendocrine cells)

Question 6

Which lung carcinoma is a tumor of mucous producing cells of the bronchioles?

Answer 6

Adenocarcinomas

Question 7

Which lung cancer has the lowest association with cigarrette smoking?

Answer 7

Adenocarcinoma

only has a SLIGHT association with cigarrette smoking

Question 8

Which lung cancer is ALWAYS associated with cigarrette smoking?

Answer 8

Squamous Cell Carcinoma

Question 9

In lung cancers, what is the most frequent site of extranodal metastasis?

**this is commonly a board question!***

Answer 9

The Adrenal Gland (most frequent)

Question 10

What are the most common sites of metastisis of lung cancer

Answer 10

Brain, bone and liver

(Adrenal gland is the most frequent site of extranodal metastisis)

Question 11

What are the diseases that comprise COPD?

Answer 11

“C-BABE”

C- COPD

B- Bronchitis

A- Asthma

B-Bronchiectasis

E- Emphysema

Question 12

What is the pathophysiology of the malignant transformation of lung cancer?

Answer 12

1. Metaplasia of bronchial epithelium (pseudostratified columnar –> Stratified squamous)- This is a reversible lesion
2. If smoking discontinued, lesion disappears and nml epithelium restored
3. If continues to smoke: metaplasia–> dysplasia–> anaplasia (an invasive squamous cell carcinoma)