Respiratory Pharmacology II Flashcards

1
Q

what causes failure of asthma management

A
  • lack of adherence to medication
  • uncontrolled co-morbid conditions
  • continued exposure to tobacco smoke, airborne pollutants, allergens, and irritants
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2
Q

what are the asthma medications for exacerbations (use mnemonic)

A
ASTHMA
Albuterol, Pirbuterol, Terbutaline
Steroids
Theophylline
Humidifier O2
Magnesium (severe exacerbation when other methods not working)
Anticholinergics
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3
Q

at what point do you add antibiotics as an additional treatment for COPD

A

when FEV1/FVC ratio is below 49%

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4
Q

mnemonic for COPD ts

A

COPD
Corticosteroids
Oxygen
Prevention (cessation of smoking, infection control, pneumococcal and influenza vaccine)
Dilators (anticholinergics and beta 2 agonists)

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5
Q

what are the opioids that are used an antitussives (cough medication)

A

codeine

dextrometorphan (synthetic codeine)

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6
Q

how do opiates work to reduce cough

A

decrease CNS cough center’s sensitivity to peripheral stimuli

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7
Q

mechanism of dextrometorphan

A

suppresses response of cough center but does not have analgesic or addictive potential and is less constipating than codeine

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8
Q

name the drug that is a mucolytic agent

A

NAC

n-acetylcysteine

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9
Q

uses of N-acetylcysteine

A
  • management of acetaminophen overdose

- cystic fibrosis to break disulfide bonds in mucus thereby liquefying it and making it easier to cough out

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10
Q

H1 antagonist used for respiratory issues

A
FLaCCiD
Fexofenadine
Loratadine
Cetirizine
Chlorpheniramine
Diphenhydramine
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11
Q

drugs used to treat chronic rhinitis

A

CCAAN

Corticosteroids: beclomethasone and flunisolide
Cromolyn
Alpha adrenergic agonists
Antihistamines
Nasal corticosteroids
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12
Q

antihistamines used to treat rhinitis

A
FLaCCCiD
Fexofenadine
Loratadine
Cetirizine
Chlorpheniramine
Cyproheptadine
Diphenhydramine
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13
Q

adverse effects of antihistamines used to tx rhinitis

A

1st gen - Chlorpheniramine, Cyproheptadine, and Diphenhydramine cross BBB and cause drowsiness

2nd gen - Cetirizine, Fexofenadine, and Loratadine do not produce drowsiness

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14
Q

mechanism of alpha adrenergic agonists

A

constrict dilated arterioles in nasal mucosa and reduce airway resistance

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15
Q

examples of alpha adrenergic agonists used in tx of rhinitis

A

phenylephrine (increase BP and dilate pupil)

pseudoephrine

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16
Q

effects of prolonged use of nasal decongestant

A

rebound nasal congestion after discontinuation of prolonged use