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Flashcards in Respiratory Deck (187)
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91

What is the MOA of theophylline?

inhibits phosphodiesterase

92

Which receptors does ipratropium antagonize in the lung?

muscarinic

93

What is the transcriptional product of NFKB?

TNFα

94

What are the two steroids used for lung inflammation?

Beclomethasone

fluticasone

95

What are the two leukotriene receptor antagonists?

Montelukast

Zafirlukast

96

What drug blocks the conversion of arachidonic acid to leukotrienes?

Zileuton

97

What is the endothelin receptor antagonist?

Bosentan

98

What is Omalizumab an antibody against? Free or receptor bound?

IgE

free

99

Which Fc receptor does IgE bind?

Fc-gamma-R1

100

What is the relationship of the pulmonary artery to the bronchus on the right and the left side?

Right = anterior

left = posterior

101

What is fungal sinusitis a complication of?

diabetes

102

What happens to the lung surface area during emphysema?

decreases

103

What is the Haldane Effect?

oxygenation of Hb promotes dissociation of H+

104

What is the Bohr Effect?

H+ dissociates O2 from Hb in peripheral tissues

105

How does the majority of CO2 get back to the lungs?

as bicarb in RBCs

106

What is the Chloride Shift?

exchage of HCO3 and chloride

107

Would ACD cause a left shift or right shift of O2-Hb dissociation curve?

right

108

What cells in the kidney is 1α-Hydroxylase located?

PCT

109

What is the Homan test? What is the Homan test indicative of?

pain on dorsiflexion of foot

DVT

110

What is Stewart-Treves Sydnrome? What causes it?

lymphangiosarcoma

long standing lymphadenitis

111

Is Lofgren Syndrome an acute or chronic sarcoidosis?

acute

112

What are the four symptoms of Lofgren Syndrome?

Hilar lymphadenopathy

fever

arthralgia

erythema nodosum

113

What is almost always the cause of Langerhans Cell Histiocytosis of the lung?

smoking

114

What are the two common presentations of Langerhans Cell Histiocytosis of the lung?

Pulmonary HTN

recurrent pneumothorax

115

Which pneumocytes are destroyed during ARDS?

Type I and Type II

116

What causes the k-Ras mutations in lung adenocarcinoma?

smoking

117

What patient population is the EGFR mutation seen during lung adenocarcinoma?

asians

118

In what populations are ALK mutations seen that lead to lung adenocarcinoma?

nonsmokers and young

119

Which cells give rise to Bronchioalveolar Carcinoma?

club cells

120

What three mutations are seen during Small cell carcinoma

Rb

p53

EGFR