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Flashcards in Renal Clearance Deck (44)
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1

What are the units of clearance?

Volume per unit time

2

What are the 3 processes in the nephron?

Glomerular Filtration
Resorption of the Substance into Blood
Secretion of the Substance into Tubule

3

What are the renal units for concentration?

mg/mL

4

What are the renal units for flow?

mL/min

5

What are the renal units for load?

mg/min

6

Pax

Concentration x in Arterial Plasma

7

Pvx

Concentration x in Venous Plasma

8

Ux

Concentration x in Urine

9

RBF

Renal Blood Flow

10

RPF

Renal Plasma Flow

11

GFR

Glomerular Filtration Rate

12

V

Urine Flow Rate

13

What is the kidney input load equal to?

Pax + RPFa

14

What is the kidney output load equal to?

(Pvx * RPFv) + (Ux * V)

15

If urine flow rate V>0mL/min then how are the values of the RFPa and RFPv affected?

RPFa > RPFv

16

What is the equation for conservation of mass in regards to renal function?

Pax + RPFa = (Pvx * RPFv) + (Ux * V)

17

What are the loads that enter the tubule?

F - filtered load
S - secreted load

18

What are the loads that leave the tubule?

R - reabsorbed load
E - excreted load

19

What is the filtered load equal to?

Pax * GFR

20

What is the excreted load equal to?

Ux * V

21

What is clearance?

It is defined as the volume of plasma completely cleared of any substance in one minute

22

What is the range of clearance?

0 to RPF (maximum)

23

What is the RPF in terms of the cardiac output?

RPF is around 25% of the cardiac output

24

How much of the RPF does the kidney filter?

20% -> this is the GFR

25

What is the formula for clearance?

Cx = Ux * (V/Px)

Px - plasma concentration of x

26

Why is the venous return ignored in clearance?

Venous blood is returned to the body

27

What happens if Cx < GFR?

Substance x is filtered and reabsorbed

28

What happens if Cx = GFR?

x is only filtered

29

What happens if Cx > GFR?

x is filtered and secreted

30

What is the clearance range for glucose and proteins?

Cx = 0 usually

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