Flashcards in Red cell Physiology Deck (12)
Describe the process of a red cell being created?
Haemotocytoblast (stem cell)
--> Proerythroblast (committed cell)
--> Reticulocyte (released into blood)
What substances are used to make RBCs?
What metals are required for RBCs?
Also copper, cobalt & manganese
What vitamins are required to make RBCs?
B12 & FOLIC ACID
Also thiamine, B6, C & E
What hormones are essential to RBC development?
Also Gm-CSF, Androgens, thyroxing & SCF
What cell breaks down RBCs?
Macrophages in the reticuloendothelial system tissues i.e. spleen, liver, lymph nodes etc
What becomes of haemoglobin after a RBC is broken down?
Globin --> Amino acids (recycled)
Haem --> Iron (recycled) & Bilirubin (excreted)
How does iron enter from the gut?
Bound to enterocytes (most ends up in your shit) and transported to the plasma by ferroportin protein
What happens to Fe once it enters circulation?
Transported around by transferrin
Then it's stored in tissues as ferritin
What does Hepcidin do?
Blocks ferroportin --> decreased iron absorption
It's produced by hepatocytes in response to inflammation
What factors can lower haemoglobin affinity for O2?