Red cell Physiology Flashcards Preview

Yr3 Haematology > Red cell Physiology > Flashcards

Flashcards in Red cell Physiology Deck (12)
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1

Describe the process of a red cell being created?

Haemotocytoblast (stem cell)
--> Proerythroblast (committed cell)
--> Erythroblast
--> Normoblast
--> Reticulocyte (released into blood)
--> Erythrocyte

2

What substances are used to make RBCs?

Metals
Vitamins
Amino acids
Hormones

3

What metals are required for RBCs?

IRON
Also copper, cobalt & manganese

4

What vitamins are required to make RBCs?

B12 & FOLIC ACID

Also thiamine, B6, C & E

5

What hormones are essential to RBC development?

ERYTHROPOIETIN
Also Gm-CSF, Androgens, thyroxing & SCF

6

What cell breaks down RBCs?

Macrophages in the reticuloendothelial system tissues i.e. spleen, liver, lymph nodes etc

7

What becomes of haemoglobin after a RBC is broken down?

Globin --> Amino acids (recycled)

Haem --> Iron (recycled) & Bilirubin (excreted)

8

How does iron enter from the gut?

Bound to enterocytes (most ends up in your shit) and transported to the plasma by ferroportin protein

9

What happens to Fe once it enters circulation?

Transported around by transferrin

Then it's stored in tissues as ferritin

10

What does Hepcidin do?

Blocks ferroportin --> decreased iron absorption

It's produced by hepatocytes in response to inflammation

11

What factors can lower haemoglobin affinity for O2?

Acidosis
Hyperythermia
Higher DPG
Hypercapnia

12

What makes up a normal adult haemoglobin (HbA)?

1 Haem Molecule
2 Alpha globin chains
2 Beta globin chains