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Flashcards in RAAS Deck (5)
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1
Q

Where does Aldosterone act on the nephron?

A

collecting duct and later part of distal convoluted tubule

2
Q

What cells does aldosterone act on?

A

principle cells and alpha intercalated cells

3
Q

what triggers aldosterone?

A

angiotensin II and high potassium

4
Q

what are the actions of aldosterone?

A

in the principle cells:

  • increase activity of sodium potassium pump to drive more sodium into the blood
  • insert potassium channels to release potassium in the urine
  • insert sodium channels to remove sodium from the urine and transport it into the blood

in alpha intercalated cells:

  • increase activity of proton pump to remove H+ from cell into urine
  • increase activity of H+/Na+ pump to remove H+ from the cell into the urine

** acid removed from the blood because the bicarb from CO2 and H2O reaction moves into the blood to neutralise.
aldosterone removes the H+ from this reaction to allow the alpha intercalated cell to work **

5
Q

what is the net effect of aldosterone on the blood?

A

lose potassium
gain sodium and therefore water
remove acid

main thing is the sodium reabsorption to increase stroke volume to increase BP