Pyrethrins/Pyrethroids/DEET Flashcards Preview

Toxicology Fall17 > Pyrethrins/Pyrethroids/DEET > Flashcards

Flashcards in Pyrethrins/Pyrethroids/DEET Deck (19)
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1
Q

From where does the main ingredient in pyrethrins come from?

A

extract from the flower

used as a home insecticide, on farm animals, and as flea and tick control in companion animals

2
Q

What are pyrethroids?

A

Synthetic analogs of pyrethrins

3
Q

What are synergized pyrethrums?

A

pyrethroids commonly formulated with a synthetic non-pesticide chemical. a synergistic effect that increases the efficacy

4
Q

What small animals are more sensitive to pyrethrins and pyrethroids?

A

Cats are more sensitive than dogs

canine topical products range from 0.054-65% permethrin

5
Q

T/F: Permethrin toxicity is one of the most common causes of poisoning in cats worldwide

A

TRUE

6
Q

What will slow down the metabolism of pyrethrins in cats?

A

They are deficient in glucuronidase transferase

7
Q

How are pyrethrins metabolized?

A

through hydrolysis and oxidation primarily in the blood and liver. Excreted in the urine

8
Q

What is the MOA of pyrethrins?

A

Neuronal membrane permeability or transport of Na and K is altered –> inhibition of repolarization –> hyper excitability of the nerve

9
Q

What type of pyrethroids have a greater effect on sodium channels?

A

Type II

10
Q

What clinical signs will be seen in cats with pyrethrin toxicity?

A

Generalized muscle tremors, depression, ataxia, salivation, vomiting, may progress to seizures and even death depending on the degree of toxicity

11
Q

What can be administered to pyrethrin toxicity patients that are having severe muscle tremors?

A

Methocarbamol

12
Q

what is the prognosis from pyrethrin toxicity?

A

Generally good - but cats are/can be the exception

timing to diagnosis and treatment is important

13
Q

T/F: DEET may be combined with other insecticides in pet products

A

TRUE

14
Q

What is deet sensitive to?

A

light

15
Q

What animals are susceptible to deet toxicity?

A

some freshwater fish, dogs and cats (Cats> dogs)

16
Q

Deet can increase _____ absorption of other products

A

dermal

17
Q

Where is deet metabolized and excreted?

A

Liver and urine

18
Q

What clinical signs will be seen in dogs and cats with deet toxicosis?

A

hypersalivation, vomiting, hyperexcitability, tremors, ataxia, seizures, skin and mm irritations

200ppm is diagnostic dose in chemical analysis

19
Q

What is the prognosis of deet toxicity?

A

Good if sublethal exposure