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Flashcards in Pumerantz Deck (15)
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1
Q

Malaria DDx

A
Influenza
Enteric fever
Bacteremia/sepsis
Dengue fever
Schistosomiasis
Leptospirosis
African tick fever
Trypanosomiasis
Yellow fever
2
Q

Thick smear

A

Can see trophozoites

3
Q

Dengue fever

A
Flavi virus from mesquito
Can be self limiting or hemorrhagic fever with shock syndrome
GI, rash, myalgia, and eye pain
Symptoms appear before 14 days
Leukopenia with elevated AST
4
Q

P. falciparum key features

A

Schizont normally in microvasculature and can only see if they are really sick
Pre-erythrocitic cycle- about 2 weeks
In RBCs, knobs (histidine rich proteins) help with ET attachment

5
Q

Yellow fever

A

Flavi virus from mesquito
Hemorrhagic with hepatic, renal, shock, and coagulopathy.
South America and sub-Saharan Africa

6
Q

Premunition

A

Infected but no symptoms

Must live in effected area

7
Q

Mechanism of quinine

A

Inhibit ETC

Blood schizonticide

8
Q

Hepatic drugs for malaria

A

Atovaquone-proquanil (also does blood) and only needed for 1 week post travel for prophylaxis.

Primaquine (can also kill hypnozoites and can cause hemolytic anemia) can be used for prophylaxis.

9
Q

RBC drugs for malaria

A

Atovaquone-proquanil (more for prophylaxis)
Doxycycline
Chloroquine (resistant species near equator can be used for prophylaxis)
Mefloquine (use if chloroquine resistant areas for prophylaxis at least 14 days after return to prevent malaria due to hepatic cycle)
Artesunate- For complicated malaria

10
Q

Severe malaria tx

A

Quinidine
Doxycycline
Artesunate

11
Q

I. scapularis

A

North part of America

Babesia, Borellia, Anaplasma

12
Q

A. americanum

A

Middle to South part of America

13
Q

Babesia Tx

A

Mild- Azithromycin, atovaquone
Severe- Quinine with clindamycin
Consider RBC exchange transfusion
Will see howell-jolly bodies if asplenic

14
Q

Radical cure

A

primaquine requires the presence of quinine or chloroquine in order to work

15
Q

Causal Prophylaxis for malaria

A

Atovaquone-proquani
Chloroquine
Target both liver and blood stages