Prop, Etom, Keta Flashcards Preview

ANPH 500 - Pharmacology - McCarver > Prop, Etom, Keta > Flashcards

Flashcards in Prop, Etom, Keta Deck (72)
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0

2,6 - di-isopropylphenol can also be found in __

Perfumes and laundry detergents

1

Dose for induction using propofol

1-2.5 mg/kg

2

Propofol chemical class

Alkyl phenol

3

What induction drug has the most rapid and complete awakening?

Propofol

4

Propofol half time

0.5 - 1.5 hours

5

Does cirrhosis or end stage renal or old age affect the elimination of prop?

No

6

Prop __ cross placenta

Can

But is rapidly cleared from fetal circulation

7

Does propofol support growth of bacteria?

Yes - E. coli and pseudomonas

8

Peds dose for prop induction

2.5-3.5 mg/kg

Due to larger central distribution and greater clearance

9

How does propofol work?

GABA receptors --> influx chlorine --> hyper polarization

10

Why not due inhalation induction on everyone?

Skip stage two with IV induction

11

Elderly need 25-50% smaller prop dose due to

Smaller central distribution volumes and decreased clearance

12

Prop conscious sedation dose in Mcg/kg/min

25-300 mcg/kg/min

13

Dose for PONV using prop

10-15 mg, followed by a 10 mcg/kg/min infusion

14

Prop dose for pruritus of neuroaxial opioids

10mg

15

Prop has anti-convulsant properties due to __

GABA mediated pre and post synaptic inhibition

16

4 things propofol does to brain

Decreases cerebral metabolic o2 requirements, cerebral blood flow, and ICP

Anticonvulsant - anti seizure
Can have uncommon induction convulsion but not seizures rt spontaneous excitatory movt of sub cortical origin

17

Prop __ change evoked potentials

Does NOT

18

Prop inhibits sympathetic vasoconstrictor nerve activity causing __

Decreased BP

19

Increase worsening of bp drop with using propofol with what factors?

Hypovolemia (dehydration)
Elderly
Dec LV fx
Aortic stenosis

20

Prop may have negative inotropic effects due to __

Decreased intracellular Ca++

21

Can you rapidly change your des while on prop and not have a CV response?

Unfortunately not

22

Should you give prop to a child with "googlie eyes" undergoing strabismus surg?

Be careful, can increase oculocardiac reflex causing bradycardia or arrest

23

Props effects on lungs of asthmatics

Bronchodilation

Reduces wheezes

24

Does prop mess with your kidneys or liver fx

No

25

Prolonged prop infusions cause green urine due to excreted __ and cloudy urine from __ acid excretion

Green urine - excreted phenols

Cloudy urine - uric acid excretion

26

Effects of propofol on ventilation

Vent depression - even worse w opioids

Dec TV and rr

Dec co2/hypoxia response

Bronchodilator

27

Prop __ IOP from induction to intubation

Lowers

28

Talk to me about prop allergy

Patients with prior exposure to di-isopropyl (perfumes/detergents/fabric softener/ skin preps)
Multiple other allergies
NMB allergies

Soy
Egg whites

29

The most common adverse effect of prop

How can we help that?

Pain on injection

Lidocaine & opioids

Larger bore IV