Flashcards in Prop, Etom, Keta Deck (72)
2,6 - di-isopropylphenol can also be found in __
Perfumes and laundry detergents
Dose for induction using propofol
Propofol chemical class
What induction drug has the most rapid and complete awakening?
Propofol half time
0.5 - 1.5 hours
Does cirrhosis or end stage renal or old age affect the elimination of prop?
Prop __ cross placenta
But is rapidly cleared from fetal circulation
Does propofol support growth of bacteria?
Yes - E. coli and pseudomonas
Peds dose for prop induction
Due to larger central distribution and greater clearance
How does propofol work?
GABA receptors --> influx chlorine --> hyper polarization
Why not due inhalation induction on everyone?
Skip stage two with IV induction
Elderly need 25-50% smaller prop dose due to
Smaller central distribution volumes and decreased clearance
Prop conscious sedation dose in Mcg/kg/min
Dose for PONV using prop
10-15 mg, followed by a 10 mcg/kg/min infusion
Prop dose for pruritus of neuroaxial opioids
Prop has anti-convulsant properties due to __
GABA mediated pre and post synaptic inhibition
4 things propofol does to brain
Decreases cerebral metabolic o2 requirements, cerebral blood flow, and ICP
Anticonvulsant - anti seizure
Can have uncommon induction convulsion but not seizures rt spontaneous excitatory movt of sub cortical origin
Prop __ change evoked potentials
Prop inhibits sympathetic vasoconstrictor nerve activity causing __
Increase worsening of bp drop with using propofol with what factors?
Dec LV fx
Prop may have negative inotropic effects due to __
Decreased intracellular Ca++
Can you rapidly change your des while on prop and not have a CV response?
Should you give prop to a child with "googlie eyes" undergoing strabismus surg?
Be careful, can increase oculocardiac reflex causing bradycardia or arrest
Props effects on lungs of asthmatics
Does prop mess with your kidneys or liver fx
Prolonged prop infusions cause green urine due to excreted __ and cloudy urine from __ acid excretion
Green urine - excreted phenols
Cloudy urine - uric acid excretion
Effects of propofol on ventilation
Vent depression - even worse w opioids
Dec TV and rr
Dec co2/hypoxia response
Prop __ IOP from induction to intubation
Talk to me about prop allergy
Patients with prior exposure to di-isopropyl (perfumes/detergents/fabric softener/ skin preps)
Multiple other allergies