Problem 3 Mind altering drugs

Question 1

Psychoactive substance in Cannabis

Answer 1

tetrahydrocannabinol (THC) (agonist)

Question 2

Endocannabinoid system

Answer 2

control system that helps regulate appetite , pain sensation, mood and memory
o Chemicals that activate it are named endocannabinoids

Question 3

Medical use of Cannabis

Answer 3

For pain and spasm, encourage eating

Question 4

Receptor (cannabis)

Answer 4

Both play a role in regulating serotonin transporter activity. Ø Both mediate inhibitory action on ongoing release of number of excitatory and inhibitory dopaminergic, GABA, glutamatergic, serotoninergic, noradrenalin and acetylcholine neurotransmitter systems, because THC binds to it. Ø CBD does not bind to CB1Rs or CB2Rs.

Question 5

How do psychedelics work

Answer 5

o All psychedelics work on a special sub-type of serotonin receptors (5HT2A/C) which play an important role in higher, cortical, brain functions
o Producing visuals (no hallucinations)
o Empathogenic: create sensation of care, love and connection to other people and the natural world
o Psilocybin disrupts “default mode” so the sense of self

Question 6

Empathogenic

Answer 6

create sensation of care, love and connection to other people and the natural world

Question 7

Harms of LSD

Answer 7

o Safest drug we know, no overdose, no physical harm, anti-addictive
o People with anxiety and inner unrest should avoid taking LSD because

Question 8

Risk of LSD

Answer 8

o Depersonalisation, anxiety, long lasting bad experience, psychosis

Question 9

Benefits of LSD

Answer 9

o May be useful treating addiction to other drugs by giving the patients a new view on their lives

Question 10

THC

Answer 10

o Main psychoactive ingredient in Cannabis

o Causes transient psychotic symptoms and increases level of anxiety, intoxication and sedation

Question 11

CBD

Answer 11

o Does not effect motor activity, body temperature or memory on its own
o Higher doses CBD potentiates the effects of low THC doses
o Has no significant effect on behaviour
o Antipsychotic effects

Question 12

Default mode network

Answer 12

“housekeeping” functions, such as memory, self-reflective thought, and the sense of our body in space

Question 13

Cannabinoid 1 receptors

Answer 13

Mainly in CNS in substantia nigra, basal ganglia, limbic system, hippocampus and cerebellum, but also in PNS, liver, thyroid, uterus, bones and testicular tissue. • Affect functions such as cognition, memory, movement and pain perception.

Question 14

Cannabinoid 2 receptors

Answer 14

Mainly in immune cells, spleen and gastrointestinal system. To some extend in CNS and PNS