Plasma Glucose: DM/Metabolic Synd Flashcards Preview

Q3 Physio II Test 3 > Plasma Glucose: DM/Metabolic Synd > Flashcards

Flashcards in Plasma Glucose: DM/Metabolic Synd Deck (13)
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1
Q

DM causes chronic what?

A

hyperglycemia (impaired glucose tolerance)

2
Q

DM caused by what?

A

1) Inability of pancreas to secrete insulin

2) Inability of tissue to respond to insulin

3
Q

Chronic DM results in what conditions?

A

Neuropathy
Vascular Dz
Infection

4
Q

Type I DM is result of what?

A

immune-mediated destruction of β cells

5
Q

Stages of development of Type I?

A

Genetic predisposition ->
Precipitating even (u/k) ->
Overt immuno abnormalities/normal insulin ->
Progressive insulin loss/Glucose normal ->
Overt DM/C-peptides ->
No C-peptides

6
Q

Clinical presentation of Type I?

A

Hypergly induces:
polydipsia
polyuria (glucosuria)

Insulin deficiency induces:
polyphagia

7
Q

Diabetic Ketoacidosis????

A

slide 97??

8
Q

Ketone Bodies produced how?

Can be used for?

A

glucagon stim FA oxidation ->
excess FA oxid makes ketone bodies

fuel for brain during fasting state

9
Q

Type II DM caused by?

A

Obesity/Inactivity
Genetics
Aging

10
Q

Insulin resistance can result in? (4)

A

Type II
HTN
Dyslipidemia
Atherosclerosis

11
Q

Type II results in what changes in insulin signaling?

A

Downregulates insulin receptors

Impairs post-receptor signaling

12
Q

Type II insulin resistance occurs mainly where?

Is result of?

A

muscles

↓ insulin receptor content -> ↓ tyrosine kinase activity

IRS1/2 (insulin receptor substrate) defects -> ↓ glucose transport

13
Q

Tissue resistance to insulin results in?

A

↑ FA storage