Physio Aging Flashcards
what is the theory of programmed senescence?
the idea that a master clock is in us, when it goes off apoptosis genes start killing cells
what is the programmed hormonal theory?
our biological clock decreases hormone secretion of IGF-1, E2, T, DHEA and melatonin
what is the programmed immunologic theory?
a chance in cytokines results in T cell function declining and increasing the chance for infection
what is the programmed theory of telomere shortening?
the idea that every time a cell divides, the telomere gets shorter - eventually getting so short that cell division stops
stochastic theories are based on what principle?
the process of living is related to environmental impacts
what is the stochastic metabolic rate theory?
the higher the BMR shorter the lifespan
a giant tortoise has a really low metabolism and can live to be 150 years old
what is the stochastic theory of glycation?
the idea that elevated glucose causes sugar to bind to molecules such as proteins and lipids, making them rigid and less functional
what is the stochastic theory of wear and tear?
accumulated debris cause cells to wear out over time and mechanically disfunction
what is the stoachastic theory of oxygen free radicals?
free radicals oxidize DNA and proteins leading to tissue damage
