Photocarcinogenesis Flashcards Preview

Year 2 Revision > Photocarcinogenesis > Flashcards

Flashcards in Photocarcinogenesis Deck (12)
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1
Q

What skin cancer arises from lifelong cumulative UV exposure?

A

SCC

2
Q

What skin cancers arise from intermittent burning episodes of sun exposure?

A

Melanoma and BCC

3
Q

What types of UV radiation cause direct and indirect DNA damage?

A

UBA - indirect

UVB - direct

4
Q

What are the 2 things produced from DNA by UVB?

A

Cyclobutane pyrimidine dimers and 6-4 photoproducts (less common but more damaging)

5
Q

What are the signature mutations produced by UVB?

A

CT or CC-TT

6
Q

How is damage from UVB repaired?

A

Nucleotide excision repair.

7
Q

How does UVA indirectly damage DNA?

A

Oxidises DNA bases and oxidised bases can pair with the wrong bases.

8
Q

What are the signature mutations of UVA damage?

A

GC-AT

9
Q

How is UVA damage repaired?

A

Base excision repair

10
Q

What mutation causes gorlins syndrome and BCCs?

A

PTCH

11
Q

What signalling pathway is commonly mutated in melanoma and what can target this?

A

Ras/Raf/MAPK

Vemurafinib

12
Q

What mutations cause familial melanoma?

A

CDKN2A and CDK4