Pharmacology and the Liver Flashcards Preview

GI 1 > Pharmacology and the Liver > Flashcards

Flashcards in Pharmacology and the Liver Deck (13)
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1
Q

Bioavailbaility

A

Drug given as a tablet/drug given as an IV injection

2
Q

Therapetuic window

A

Less than toxic drug concentration but greater than minimum

3
Q

Hepatic metabolis

A

Lipophilic drugs not eliminated by kidney so diffuse back into blood…liver metabolize and the metabolites eliminated in the urine or bile

4
Q

Biliary excretion

A

Good for large and hydrophilic drugs

If already hydrophilic, may enter as a charged drug

Others are may hydrophic by conjugated

5
Q

If elimination slows

A

Renal failure is ex

Peak conc is higher and delayed

AUC inc

6
Q

Albumin
alpha 1 acid glyco protein
Lipoproteins

A

Binds weak acids and is most abundant and important

For basic

For lipophilic

7
Q

Phases of metabolism

A

1 - oxidation

2 - attach polar molecule in conjugation

8
Q

Isonizaid

A

Neutiris and hepatotoxicyt

9
Q

Rifampin

A

Hepatotoxicity and P450 inducer

10
Q

Pyrazinamide

A

Hepatitis

11
Q

Ribavirin

A

Disrupts viral replication

12
Q

Sofosbuvier and ledipasvir

A

Sof - inhibitor of NS5B and RDRP

Led - inhibits NS5A….needed for replication

13
Q

Paritaprevir

A

NS3-4A inhibt which is a viral protease

Does NOT cure the infection