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Flashcards in Pharmacology Deck (10)
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1

What are the 2 groups/classifications of cytotoxic therapy?

Cell cycle -specific
Non cell cycle -specific

2

Cell cycle -specific cytotoxic therapy is relatively tumour specific. The dosage is more important than the duration of exposure. True/False?

False
Duration of exposure is more important than dosage

3

What are the 2 main cell cycle -specific cytotoxic agents?

Antimetabolites
Mitotic spindle inhibitors

4

List some examples of antimetabolite cytotoxic agents

Methotrexate
6-Mercaptopurine
Hydroxyurea

5

List some examples of mitotic spindle inhibitors

Vincristine
Taxotere

6

Non cell cycle -specific cytotoxic therapy is not tumour specific. The dosage is more important than the duration of exposure. True/False?

True

7

List some examples of non cell cycle -specific cytotoxic agents

Chlorambucil
Carboplatin
Cis-platinum

8

List some immediate side effects of cytotoxic therapy

Bone marrow suppression
Gut mucosal damage
Hair loss

9

What is the emergency treatment for neutropenic sepsis?

Piperacillin/Tazobactam
+ gentamicin if severe

10

Which antibody-drug conjugate is used as targeted chemotherapy for non-Hodgkins lymphoma?

Brentuximab Vedotin