Pharmacogenetics Flashcards Preview

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Flashcards in Pharmacogenetics Deck (6)
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1
Q

What are the four genotypes for metabolism?

A

UltraRapid: Substancially increased metabolic activity

Extensive: Normal

Intermediate: Reduced

Poor: Little to no functional activity

2
Q

Differentiate Prodrug vs active drug.

A

Prodrug: Inactive until they are metabolized

Active drugs: Inactivated during metabolism

3
Q

Which Cytochrome P450 is most studied and has high involvement in many medications?

A
  • Debrisoquine hydroxylase or CYP2D6
4
Q

What is the 2nd most studied Cytochrome p450? What drugs are they involved in?

A

CYP2C19

  • Proton Pump Inhibitor
  • Antidepressants
5
Q

What drugs and affects are associated with CYP2C9?

A
  • Medications with narrow therapeutic windows such as Warfarin and Tolbutamide
  • Vitamin K epoxide reductase complex subunit 1 is responsible for pharmacodynamics of Warfarin
6
Q

What is the importance of TPMT in drug metabolism?

A
  • Thiopurine methyltransferase
  • Regulates balance between cytotoxic thiguanine nucleotide and inactive metabolite in hematopoietic cells
  • ** 6-MP Metabolism
  • ** Azothioprine metabolism