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Flashcards in Pharm- anticoagulants Deck (23)
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1

Heparin- Indications

Prevention of DVTs, treatment of PEs, pregnancy

2

Heparin- MOA

Binds to antithrombin III, inactivates coagulation factors

3

Heparin- AE

hemorrhage, thrombocytopenia, hypersensativity

4

Heparin- Monitoring

Bleeding time

5

LMWH- Indications

Prophylaxis of DVT, MI,

6

LMWH- MOA

Selectively accelerates interaction of antithrombin with factor Xa

7

LMWH- AE

Fewer than heparin, less frequent bleeding,

8

Fondaparinux- Indications

Prophylaxis of DVT, acute PE & DVT in combination with warfarin.

9

Fondaparinux- MOA

Selectivly inhibits factor Xa by selectivly binding to antithrombin III

10

Fondaparinux- AE

Bleeding, no throbocytopenia

11

Warfarin- Indications

Prevention of progression or recurrence of DVT or PE following initial heparin tx. Prophylaxis of MI, a-fib

12

Warfarin- MOA

Antoagonize cofactor function of Vit. K

13

Warfarin- AE

Black box for bleeding, pregnancy, drug-drug interactions

14

Warfarin- Monitoring

INR regularly to adjust dose

15

Dabigatran- Indications

Prevention of stroke, embolism, a-fib. Does not require INR

16

Dabigatran- MOA

Direct thrombin inhibitor

17

Dabigatran- AE

Bleeding, GI, fewer drug-drug interactions than warfarin

18

Rivaroxaban- Indications

Prophylaxis of DVT, stroke, PE

19

Rivaroxaban- MOA

Selective inhibition of factor Xa

20

Rivaroxaban- AE

Risk of thrombosis with discontinuation, Bleeding, epidural/ spinal hematoma, back pain

21

Apixaban- Indications

Prophylaxis of DVT, stroke,

22

Apixaban- MOA

Selectively inhibits factor Xa

23

Apixaban- AE

Risk of thrombosis with discontinuation, Bleeding, epidural/ spinal hematoma, anemia