acetaminophen MOA
decrease syn of prostaglandins
NSAIDs
inhibit Cox I
when to stop ASA before sx
other NSAIDs
1 week
3-5 days
when should you avoid morphine
head trauma
methadone
opioid agonist and NMDA antag
beta lactams can induce this type of hypersensitivity
type I
1st gen cephs
skin
2nd gen cephs
Upper respiratory
PID
3rd gen cephs
pneumonia + CNS
vanco
red man syndrome, oto/nephro toxic
tetacycline MOA
amingoglycosides
30s
clinda MOA
macrolides
50s
good for PCN/ceph allergy
FQ MOA
DNA gyrase
Bactrim MOA
block folate
what to monitor with INH
monitor LFTs, give B6, drug induced lupus
furosemide
ascending loop of henle
Non-dihydro
verapamil-affects contractility
diltiazem-angina/antiarythmias
SE constipation
dihydro
amlodipine
vasodilation
Digoxin
+ inotrope, used for HF/a-fib
glitazones
BBW for MI
what drug can be used to prevent tumor lysis syndrome
allopurinol
carbamezapine SE
aplastic anemia, prevent Na influx
phenytoin SE
gingival hyperplasia, osteoperosis, megaloblastic anemia
supplement with folate, Ca, Vit D
what to monitor for valproate
LFT
doxorubicin SE
cardiotoxicity
Bleomycin
pulmonary fibrosis
5-FU SE
mucositis
cisplatin SE
peripheral neuropathy
ototoxicity
cyclophosphamide SE
hemorrhagic cystitis
adenosine and dipyramidole moa
vasodilation of coronary arteries
Maoi can cause
HTN
Tyrosine kinase inh are usedul for
CML
Hydralazine is used in conj with
Isosorbide dinitritr
HIV regimen
2 NRTIs + 1 other class
argatroban
direct thrombin inhibitor
clopidogrel
p2Y12 receptor inhibitor
tamoxifen
prevent breast cancer lowers LDL increase bone density increases risk for endometrial/uterine cancer a/w increased risk of VTE
what drugs effect warfarin
ketoconazole, INH, cimetidine
drugs that cause dru induced lupus
procainamide, methyldopa, hydralazine
this drug can cause depression, fatigue, insomnia, appetitie change
propranolol
SE of heparin
osteoperosis
hyperkalemia
thiazide diuretics can cause
hyponatremia
tyramine MAO OD can lead to
HTN crisis
best drug to treat hypertryglycerides
fibrates
however, they increase gallstone formation so use in caution w/GB disease
lithium SE
hyperparathyroid, hypercalcemia, nephogenic DI, CKD, thyroid dysfunction, teratogenic
drugs that cause QT prolongation
antipsychotics
FQs
macrolides
HIT tx
switch to argatroban, fondaparinux
digoxin SE
cardiac arrythmias
confusion
blurred vision/color
elevated K
hypokalemia typically occurs also with
hypomagnesia