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Flashcards in pharm Deck (16)
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1
Q

what pts are oral agents: insulin secretagogues (promotes secretion) / oral glucose lowering agents

A

pt c/ type II diabetes who cannot be managed by diet alone

2
Q

T/F oral glucose should not be given to pts c/ type I Diabetes or because of progressive decline in Beta cells that occurs due to dz or aging

A

True

3
Q

what is the MOA of sulfonylureas

A

promote insulin secretion from Beta cells of the pancreas

4
Q

what oral hypoglycemic agent has a duration of action >24hrs

A

Pioglitazone (Actose)

5
Q

what classes of oral agents are considered insulin secretagogues (promote secretion)

A

sulfonylureas , glinides

6
Q

what classes are considered insulin sensitizers

A

Biguanides, thiazolidinediones

improve insulin action. lower BS by improving target cell response to insulin without inc pancreatic insulin sectretion

7
Q

in type II diabetes what is a major source of/ accounts for the high BS on waking

A

excess glucose produced by the liver

8
Q

what are some bonus- of taking metformin

A

can modestly reduce LDL, VLDL and inc HDL

9
Q

when should you D/C metformin

A

if undergoing procedure requiring contrast

10
Q

what does long term use of metformin interfere with

A

absorption of B12

11
Q

is hyperinsulinemia a risk with glitazones

A

no, although insulin is required for their axn, these drugs do not promote insulin release from Beta cells

12
Q

what 2 meds can cause ovulation to resume in premenopausal women with polycystic ovary syn

A

metformin and TZDs (thiazolidinediones) glitazones e.g. pioglitazone (Actos)

13
Q

what drugs neither stimulate insulin release nor inc insulin action on target tissue

A

alpha glucosidase inhibitors e.g acarbose

14
Q

what classes of oral agents improve insulin axn

A

biguanides and thiazolidinediones

15
Q

which classes of glucose lowering agents have the ability to reduce insulin sensitivity

A

thiazolidinediones and biguanides

16
Q

a 64 y/o woman c/ a Hx of type II DM and HF what med would you not want to give her

A

pioglitazone- fluid retention can worsen HF