Pathophysiology of Ovarian Cancer

Question 1

Which serum marker is elevated in women with epithelial ovarian cancer?

Answer 1

CA125

Question 2

How does epithelial ovarian cancer spread?

Answer 2

peritoneal dissemination, direct extension, lymphatic and hematogenous spread

Question 3

Peritoneal spread is in what direction?

Answer 3

clockwise while looking @pt due to bowel peristalsis

Question 4

Most lethal gyn malignancy

Answer 4

epithelial ovarian cancer

Question 5

T/F there is no screening test for epithelial ovarian cancer

Answer 5

T

Question 6

CA125 is a good tumor marker for:

Answer 6

serous epithelial ovarian cancer

Question 7

Ca19-9 is a good marker for :

Answer 7

mucinous epithelial ovarian cancer

Question 8

ovarian LMP tumors present at older/younger age

Answer 8

younger

Question 9

Ovarian LMP tumors have benign/malignant clinical course

Answer 9

benign (low malignant potential)

Question 10

Peritoneum is considered the _____ and is under the same influences as the ovarian surface epithelium

Answer 10

secondary mullerian system

Question 11

___ appears microscopically the same as ovarian adenocarcinoma but no stromal involvement

Answer 11

perimary peritoneal cancer

Question 12

T/F Tumor debulking is effective in the tx of ovarian cancer

Answer 12

T

Question 13

Ovarian cancer chemo

Answer 13

carboplatin/paclitaxel for early high risk –> carboplatin/paclitaxel/doclitaxel for later stage