Pathogenesis (lec 3) Flashcards Preview

Q3 Microbiology test 1 > Pathogenesis (lec 3) > Flashcards

Flashcards in Pathogenesis (lec 3) Deck (15)
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1
Q

Colonization is?

A

Transiently/permanently established microbe

No interference

2
Q

Infection is?

A

Colonization w/ tissue invasion and multiplication

(P) progress to disease

3
Q

Disease is?

A

Abnormal fxn/structure

Host damage

4
Q

Virulence is?

A

degree of pathology caused by pathogen

5
Q

Koch’s Postulates?

A

Isolate/identify by growth in pure culture

6
Q

Mullis’ Polymerase Chain Rxn?

A

Isolation/identification thru nucleic acid amplification (match gene sequence to known sequence)

7
Q

Endogenous bacteria is?

A

Opportunistic, part of normal microbiota

e.g staph epidermis -> blood

8
Q

Exogenous bacteria is?

A

Bacteria NOT part of normal microbiota,
introduced from outside body
Opportunistic (U) to compromised immune systems

9
Q

Virulent/Strict pathogens

A

Always cause disease:
Damage/loss of tissue/organs,
Inflammatory response

e.g. m. tuberculosis, n. gonorrhoeae

10
Q

Mechanism of Virulence: Metabolites?

A

tissue damaging by-products (acids, gases)

11
Q

Mechanism of Virulence: Enzymes?

A

spreading factor:

  • act locally or affect tissue matrices/intercellular spaces
  • facilitate spread and growth of pathogen
12
Q

Types of Virulence Enzymes? (4)

A

1) Hyaluronidase: attacks hyaluronic acid of CT
2) Collagenase: attacks collagen in mm, tendons, ligaments
3) Neuraminidase: attacks neu. acid (intercellular cement) of epithelial cells of intestinal mucosa
4) Strepto/Staphylokinase: prevents clotting (Fibrinolysins)

13
Q

Mechanism of Virulence: Adhesion?

A

Bacterial ligand binds hosts’ receptor

(U) carb moieties of glycoproteins

14
Q

Methods of adhesion?

A

Fimbrial/Pili

Afimbrial: proteins in cell envelope (glycocalyx)

15
Q

Mechanism of Virulence: Toxins

Exotoxins?

A

Proteins from G+ and G-:

toxic by direct action
bind host receptors
secreted into extracellular fluid or a/w cell surface