Part 3: Muscle Growth and Repair Flashcards Preview

SF1.12 Muscle Physiology (ZACHOW) > Part 3: Muscle Growth and Repair > Flashcards

Flashcards in Part 3: Muscle Growth and Repair Deck (37)
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Lower intensity endurance training results in an increase in:

  • an increase in type 1 muscle fiber:
    • oxidative capacity
    • mitochondria
    • capillary density


Physical training at high levels of resistance will result in:

  • hypertrophy of type 2 muscle fibers (fast-twitch) with a modest effect on the aerobic (oxidative) capacity of these fibers.


Two anabolic androgenic steroids:

  • testosterone and dihydrotestosterone
  • effects mediated through the activation of the androgen receptor 


What occurs when anabolic androgenic steroids bind to androgen receptors?

  • anabolic (proteogenic) effects
  • anti-catabolic (competitive binding to glucocorticoid receptor) effects


Anabolic (proteogenic) effects of testosterone and dihydrotestosterone binding to androgen receptors:

  • Stimulation of:
    • satellite cell proliferation
    • growth hormone (GH) secretion
    • insulin-like growth factor-1 (IGF-1) expression 


Growth hormone (GH) secretion site and function:

  • secreted from somatotropes (anterior pituitary)
  • induces positive nitrogen balance and proteogenesis
  • stimulates hepatic IGF-1 production


Insulin-like growth factor-1 (IGF-1) secretion site and function:

  • ubiquitously expressed in skeletal muscle 
  • stimulates proteogenesis
  • stimulates regeneration (induces satellite cell mitosis)