Flashcards in Pancytopenia Deck (13)
What is pancytopenia?
A deficiency in blood cells of all lineages (RBC, platelets, granulocytes)
Generally excludes lymphocytes
Pancytopenia is caused by reduced production or increased destruction of cells. True/False?
Fanconi'a anaemia is an inherited marrow failure syndrome. What is the defect?
Failure to repair DNA damage
List the main acquired primary bone marrow failures that result in pancytopenia
What happens in aplastic anaemia?
Autoimmune attack against haemopoietic stem cells
List the main causes of secondary bone marrow failure
Drugs (chemotherapy, chloramphenicol)
What condition is notorious for causing increased destruction of blood cells?
List some causes of hypersplenism
Splenic congestion (heart failure, hypertension)
List clinical features of pancytopenia (think anaemia, neutropenia and thrombocytopenia)
List investigations for pancytopenia
Blood count and film
Guided tests (LFTs, folate/B12, virology, antibodies)
Bone marrow aspirate
Outline supportive treatment for pancytopenia
Outline treatment for pancytopenia caused by primary marrow disorder
Bone marrow transplant