Pancreas, Liver, Gallbladder (lec 4) Flashcards
Pancreatic juice fxn? (2)
1) neutralize stomach acid
2) make digestive enzs
Amylase does?
carb digestion
Lipase does?
lipid digestion to FA, monogly, cholestrol
Protase does?
digest proteins to AA
Pancreas Acinar cells fxn?
secrete enzym component of pancr juice
Pancreas Centroacinar fxn?
secrete aqueous component of pancr juice (isotonic electrolytes and HCO3-)
Pancreas Ductal cells fxn?
modify juice: remove Cl-, add HCO3-
Composition of pancreatic juice Δs depending on?
rate of secretion
- however, regardless of flow:
- juice is always isotonic
- [Na+ and K+] always same as [plasma]
[HCO3- and Cl-] at low secretion rate?
HCO3- lowest
Cl- highest
[HCO3- and Cl-] at high secretion rate?
HCO3- high
Cl- low
Pancreatic juice secretion during Cephalic digestion mediated how?
vagus (PNS/ACh)
enz @ 25% of max
aqueous @ 15% of max
Pancreatic juice secretion during Gastric digestion mediated how?
distension (vagovagal reflex)
Gastrin
enzs more effected
Pancreatic stim in Intestinal digestion by?
(controls 80%)
gastric by-products
Fat/protein by-products in duodenum stim pancreatic secretions how?
stim I cells -> release CCK
CCK stim pancreatic secretion how?
travels to pancreas thru circulation ->
stim acinar cells ->
↑↑ enz and ↑ aqueous secretions