Pancreas, Liver, Gallbladder (lec 4) Flashcards

1
Q

Pancreatic juice fxn? (2)

A

1) neutralize stomach acid

2) make digestive enzs

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2
Q

Amylase does?

A

carb digestion

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3
Q

Lipase does?

A

lipid digestion to FA, monogly, cholestrol

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4
Q

Protase does?

A

digest proteins to AA

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5
Q

Pancreas Acinar cells fxn?

A

secrete enzym component of pancr juice

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6
Q

Pancreas Centroacinar fxn?

A

secrete aqueous component of pancr juice (isotonic electrolytes and HCO3-)

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7
Q

Pancreas Ductal cells fxn?

A

modify juice: remove Cl-, add HCO3-

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8
Q

Composition of pancreatic juice Δs depending on?

A

rate of secretion

  • however, regardless of flow:
  • juice is always isotonic
  • [Na+ and K+] always same as [plasma]
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9
Q

[HCO3- and Cl-] at low secretion rate?

A

HCO3- lowest

Cl- highest

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10
Q

[HCO3- and Cl-] at high secretion rate?

A

HCO3- high

Cl- low

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11
Q

Pancreatic juice secretion during Cephalic digestion mediated how?

A

vagus (PNS/ACh)

enz @ 25% of max
aqueous @ 15% of max

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12
Q

Pancreatic juice secretion during Gastric digestion mediated how?

A

distension (vagovagal reflex)
Gastrin

enzs more effected

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13
Q

Pancreatic stim in Intestinal digestion by?

A

(controls 80%)

gastric by-products

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14
Q

Fat/protein by-products in duodenum stim pancreatic secretions how?

A

stim I cells -> release CCK

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15
Q

CCK stim pancreatic secretion how?

A

travels to pancreas thru circulation ->
stim acinar cells ->
↑↑ enz and ↑ aqueous secretions

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16
Q

H+ gastric by-product in duodenum stim pancreatic secretions how?

A

stim S cells -> release Secretin

17
Q

Secretin stim pancreatic secretions how?

A

cause ductal cells to ↑ aqueous production (HCO3-)

18
Q

Liver fxns? (6)

A

1) regulate glucose
2) reg vascular volume
3) detox
4) metabolize cholesterol
5) synth plasma proteins
6) digest/absorb fats

19
Q

Bile is?

Stored?

Secreted?

Fxn?

A

liver product

stored in gallbladder

secreted into small intest

aids fat digestion/absorb,
transport/eliminate cholesterol

20
Q

Portal Triads are?

A

bile duct/artery/vein at ea corner of liver

21
Q

Bile made of?

A

Bile salts
phospholipids
other stuff

22
Q

Bile salts are hydro- what?

A

philic AND phobic

23
Q

Bile salts formed where?

A

hepatocytes from cholesterol

24
Q

Primary bile acid made where?

Of?

A

liver

cholic and chenodeoxycholic acids

25
Q

Secondary bile acids made where?

Of?

A

intestin by bacteria

deoxycholic and lithocholic acids

26
Q

Conjugated bile (bile salt) is/does?

A

Bile acids combined w/ Glycine or taurine, lowers pK to < 4 so they stay soluble in duo and can emulsify fats

27
Q

Bile salts digest fat how?

A

emulsification of fat droplets,

formation of micelles

28
Q

How does emulsification ↑ fat digestion?

A

↑ SA for pancreatic lipase to act on fat droplets

29
Q

Micelles ↑ fat digestion how?

A

hphilic heads face aqueous environment,

hphobic hidden inside

30
Q

Bile salts reabsorbed from enterocirculation how?

A

Na+ co-transport in ileum ->

portal vein to liver

31
Q

Synth of new bile salt regulated by?

A

amount of bile salt reabsorbed

32
Q

Gallbladder empties into duodenum thru?

A

sphincter of Oddi

33
Q

CCK effects on gallbladder?

A

(PNS/ACh)
contract GB
relax Oddi

34
Q

Summary: CCK effects on pancr/biliary secretions?

Released by?

Released from?

A

STIMULANT

1) GB contraction
2) Panc enz secretion
3) Oddi relax

proteins/FA

duo/jej I cells

35
Q

Summary: Secretin effects on pancr/biliary secretions?

Released by?

Released from?

A

STIMULANT

1) pancr HCO3- secretion
2) liver HCO3- and H2O secretion
3) ↑ bile prxn

H+

duo/jej S cells