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Human disease and therapeutics 2020 > Pain treatment lecture 2 > Flashcards

Pain treatment lecture 2 Flashcards

1
Q

What do Ibuprofen type NSAIDs do?

A

-COX 1 and COX 2 inhibitor

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2
Q

What amount of Ibuprofen is needed for an analgesic effect?

A

-400 mg

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3
Q

What amount of ibuprofen is needed for anti-inflammation?

A

-800 mg

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4
Q

What type of pain do you use ibuprofen for?

A

-Mild to moderate pain relief

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5
Q

What are the side effects of ibuprofen type NSAIDs?

A
  • GI ulcers
  • Anti-clotting
  • Cardiovascular effects
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6
Q

What amount of ibuprofen is needed for antipyretic action?

A

-400 mg

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7
Q

What type of people should you be cautious in giving ibuprofen?

A
  • Heart disease
  • High blood pressure
  • Diabetes
  • Strokes
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8
Q

What are some special properties of ibuprofen like NSAIDs?

A
  • Ketoprofen (Orudis)

- Naproxen (Naprosyn)

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9
Q

How does ketoprofen compare to ibuprofen?

A

-More potent at lower doses

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10
Q

How does Naproxen (alleve) compare to Ibuprofen?

A

-Longer lasting and slower acting

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11
Q

Why would you use Celecoxib?

A

-Lacks GI and anti-clotting action because it is a COX-2 selective antagonist

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12
Q

T/F Celecoxib has been linked with cardiovascular side effects

A

True

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13
Q

What are some other NSAID agents? (these are used in arthritis)

A
  • Indomethacin
  • Meloxicam
  • Diflunisal (Dolobid)
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14
Q

What is Indomethacin?

A

-Potent non-selective NSAID/due to side effects not a common analgesic

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15
Q

What is Meloxicam?

A
  • Preferentially inhibits COX-2 over COX-1 which means less GI problems
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16
Q

What is Diflunisal (Dolobid)?

A

-Related to salicylates and is supposed to be good for bone pain

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17
Q

What are the possible mechanisms of Acetaminophen?

A

-Inhibits a COX3 enzyme or serotonin

18
Q

What are the side effects of acetaminophen?

A
  • Liver toxin in high doses

- Pts with compromised livers should not use

19
Q

What are the analgesic uses of NSAIDs?

A
  • Somatic pain

- Mild to moderate pain

20
Q

What type of somatic pain could you use NSAIDs for?

A
  • Most dental pain
  • Most headaches (Tension and congestion types not migraines)
  • Most muscle and joint pains
  • Most earaches
21
Q

What are some NSAID contraindications?

A
  • Pt on anticoagulants
  • Hemophiliac
  • Ulcers
  • Already taking high doses
  • Child or adolescent
  • History of allergies
22
Q

What are some anticoagulants?

A
  • Coumadin (Warfarin)/ Pradaxa
  • Joint replacement
  • Heart attack/ stroke
  • Major surgery
  • Atrial fibrillation
23
Q

What are some signs of a possible ulcer?

A
  • Frequent upset stomach
  • Bleeding in stool
  • Take antacids
  • Takes H2 blockers (tagamet)
24
Q

What are the therapeutic uses of opioid narcotics?

A
  • Analgesia
  • Somatic and visceral pain
  • Mild to severe
  • Antitussive (blocks the coughing center)
  • Antidiarrheal
25
Q

What are six of the most commonly used narcotics?

A
  • Morphine
  • Hydromorphone
  • Oxymorphone
  • Oxycodone
  • Hydrocodone
  • Codeine
26
Q

What are the more potent forms of narcotics?

A

-Morphine/morphones

27
Q

What is a less potent narcotic?

A

-Codeine/Codone

28
Q

Are hydros or oxys more potent?

A

-Oxy

29
Q

What type of narcotics are lortab and vicodin?

A

-Hydrocodone + acetaminophen

30
Q

What is Meperidine (Demerol)?

A

-Narcotic analgesic for moderate pain

31
Q

What is Pentazocine (Talwin)?

A

-A Narcotic analgesic that is a Mixed agonist/antagonist that treats moderate pain

32
Q

What is methadone?

A

-Narcotic analgesic for moderate to strong pain that is used to treat opioid addiction and as an analgesic

33
Q

What is Buprenorphine?

A

-Narcotic analgesic for moderate analgesic mixed agonist and antagonist that is used to treat opioid addiction

34
Q

What is one of the most potent narcotics?

A

-Fentanyl .1 mg

35
Q

What are the major opioid agonist side effects?

A
  • Respiratory depression
  • Decreased pulmonary reflex
  • Constipation/slow bowel movement
  • Sedation/additive or synergistic with other CNS depressants
  • Euphoria/dependence/addiction
36
Q

What is the treatment for opioid overdose?

A

-Inject naloxone (Narcan)

37
Q

What type of drug is Oxycontin/Percodan?

A

-Oxycodone

38
Q

What are contraindications for opioids?

A
  • History of substance abuse
  • Sever constipation or upset stomach
  • Respiratory problems
  • CNS depressants
  • Allergies
39
Q

When managing neuropathic pain what is the first line treatment drugs?

A
  • Gabapentin
  • Duloxetine
  • Nortriptyline
40
Q

What is the next line of treatment of managing neuropathic pain?

A

-Tramadol

Human disease and therapeutics 2020 (60 decks)

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