What is the predominant peripheral blood leukocyte in rats?
True or False: Female rats have lower total leukocyte counts?
Polyploidy is a common morphological feature in ______ animals.
What is a common liver manifestation of decreased or absence of food intake?
Marked atrophy of hepatic cords
When is proteinuria normal in rats?
During tubular production of alpha globulins
When is proteinuria abnormal in rats?
When serum proteins are lost
Do rat bones possess Haversian systems?
True or False: Hematopoiesis in long bones stops at 6 months?
False - remains active throughout life
True or False: Rats have more extensive splenic hematopoiesis than mice.
False - it may indicate disease in rats
What accumulates in splenic macrophages throughout life, especially in breeding females?
What type of cells in the respiratory epithelium are unique to rats?
Who has the larger adrenals – male or female rats?
Do young or old male rats have epithelial megalokaryocytes of the exorbital lacrimal glands?
True or False: The wild rat cytomegalovirus is antigenically similar to mouse cytomegalovirus.
False - distinct
Name the 3 major genetic/antigenic groups of rat parvoviral infections.
Kilham's rat virus (RV)
Rat Parvovirus (RPV)
Which rat parvoviruses cause naturally occurring disease?
Kilham's rat virus (RV)
What are the clinical signs for RV?
ruffled hair coat
Hemorrhages in hepatocytes, bone marrow, cerebrum, cerebellar cortex, kidney, lung, genital tract are due to what process?
Endothelial cell and megakaryocyte damage associated with RV replication in these tissues
Why might dogs and cats have intestinal mucosal lesions due to parvo infection and not rats?
This is likely due to a lack of viral receptors on rat enterocytes
Besides SDAV, what other virus is in the coronavirus grouping?
Parker’s Rat Coronavirus
The reparative stages of SDAV begin when?
7-10 days post-exposure
The majority of the SDAV repair is complete by what day postexposure?
14 days post-exposure
The genus Hantavirus belongs to which family?
Which two syndromes represent the 2 major lineages of hantaviruses?
Hemorrhagic Fever and Renal Syndrome (HFRS)
Hantavirus Pulmonary Syndrome (HPS)
Humans are what type of host for hantaviruses?
Compare the clinical signs of a rat and a human infected with hantaan virus.
The rat produces no clinical evidence of disease.
Human cases of HFRS: fever, thrombocytopenia, capillary leakage resulting in myalgia, headache, petechiation, with prominent retroperitoneal and renal hemorrhage.
Human cases of HPS: fever, capillary leakage localized to lungs. Death occurs from shock and cardiac complications.
The paramyxovirus, Pneumonia Virus of Mice (PVM), infects which species?
Mice, Rats, Hamsters, Gerbils
The acute multifocal nonsuppurative vasculitis and interstitial alveolities with necrosis and BALT hyperplasia of PVM results in what clinical signs?
True or False: A rat may become infected with the paramyxovirus, Sendai virus, from a hamster?
Is the Sendai virus an upper or lower respiratory disease?
Both - it replicates and causes lesions in the upper and lower tract.