Oxybutynin Flashcards Preview

Block 6 PHARMACOLOGY > Oxybutynin > Flashcards

Flashcards in Oxybutynin Deck (7)
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1
Q

what is oxybutynin?

A

A muscarinic acetylcholine receptor antagonist.

2
Q

what is oxybutynin used to treat

A

to relieve urinary and bladder difficulties

3
Q

what does oxybutynin competitively antagonize and what are the effects

A

the M1, M2, and M3 subtypes of the muscarinic acetylcholine receptor and so reduce detrusor activity

4
Q

which isomer does most if the antimuscarinic activty of oxybutymin occur

A

R isomer

5
Q

what two isomers is oxybutynin made of?

A

R and S

6
Q

what extensively metabolizes oxybutynin?

A

by the cytochrome P450 enzyme systems, particularly CYP3A4, found mostly in the liver and gut wall

7
Q

how much of the adminstered dose of oxybutynin is excreted unchanged in the urine?

A

less than 0.1%